(2E)-N-(3-FLUOROPHENYL)-2-(HYDROXYIMINO)ACETAMIDE

Base Information

• Chemical Name: (2E)-N-(3-FLUOROPHENYL)-2-(HYDROXYIMINO)ACETAMIDE
• CAS No.: 350-78-7
• Molecular Formula: C8H7 F N2 O2
• Molecular Weight: 182.154
• Hs Code.: 2928000090
• Mol file: 350-78-7.mol

Synonyms:Glyoxylanilide,3'-fluoro-, oxime (6CI); N-(3-Fluorophenyl)-2-hydroxyiminoacetamide

Chemical Property of (2E)-N-(3-FLUOROPHENYL)-2-(HYDROXYIMINO)ACETAMIDE

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 65.18000
• Density: 1.3g/cm³
• LogP: 1.87370

Purity/Quality:

98% ^*data from raw suppliers

N-(3-fluorophenyl)-2-(N-hydroxyimino)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2E)-N-(3-FLUOROPHENYL)-2-(HYDROXYIMINO)ACETAMIDE

There total 4 articles about (2E)-N-(3-FLUOROPHENYL)-2-(HYDROXYIMINO)ACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

meta-fluoroaniline (372-19-0) + chloral hydrate (302-17-0) → 3-fluoro-isonitrosoacetanilide (350-78-7,1888389-19-2)

Guidance literature:

With hydrogenchloride; hydroxylamine hydrochloride; sodium sulfate; In water; at 35 - 90 ℃; for 2h;

DOI:10.1080/00397910903318591

Reference yield:

meta-fluoroaniline (372-19-0) + chloral (75-87-6) → 3-fluoro-isonitrosoacetanilide (350-78-7,1888389-19-2)

Guidance literature:

With hydroxylamine hydrochloride; sodium sulfate; In water; at 50 ℃; for 5h;

Reference yield:

meta-fluoroaniline (372-19-0) + chloral hydrate (302-17-0) → (2E)-N-(3-fluorophenyl)-2-hydroxyiminoacetamide (350-78-7,1888389-19-2)

Guidance literature:

With hydrogenchloride; hydroxylamine; sodium sulfate;

upstream raw materials:

meta-fluoroaniline

chloral hydrate

chloral

Downstream raw materials:

6-fluoroisatin

2-(6-fluoro-1H-indol-3-yl)acetonitrile

7-fluoro-2-methyl-quinoline-4-carboxylic acid

2-(6-fluoro-2,3-dioxoindolin-1-yl)-N-phenylacetamide

Refernces

• 1、 -. "METHOD FOR PRODUCING 4-FLUOROISATIN DERIVATIVE". Paragraph 0110. . Retrieved 2017/02/09.
• 2、 -. "NITROGENATED HETEROCYCLIC COMPOUND AND AGRICULTURAL OR HORTICULTURAL FUNGICIDE". Paragraph 0379; 0380. . Retrieved 2014/03/25.