(R)-(-)-alpha-Methoxyphenylacetic acid

Base Information

• Chemical Name: (R)-(-)-alpha-Methoxyphenylacetic acid
• CAS No.: 3966-32-3
• Molecular Formula: C9H10O3
• Molecular Weight: 166.177
• Hs Code.: 29189900
• European Community (EC) Number: 223-580-9
• UNII: WA8N5X9TFK
• Mol file: 3966-32-3.mol

Synonyms:3966-32-3;(R)-(-)-alpha-Methoxyphenylacetic acid;(R)-2-Methoxy-2-phenylacetic acid;(2R)-2-methoxy-2-phenylacetic acid;MFCD00004250;WA8N5X9TFK;Methoxy(phenyl)acetic acid #;Methoxyphenylacetic acid, (-)-;(R)-METHOXYPHENYLACETIC ACID;EINECS 223-580-9;(R)-(-)-.alpha.-Methoxyphenylacetic acid;(2R)-2-Methoxy-2-phenyl-acetic acid;(R)-(-)-alpha-MethoxyphenylaceticAcid;Benzeneacetic acid, .alpha.-methoxy-, (R)-;SCHEMBL104518;(R)-methoxy-phenyl-acetic acid;(R)-(+)-Methoxyphenylacetic acid;(R)-(-)-.ALPHA.-MPA;(R)-2-phenyl-2-methoxyacetic acid;(RS)-2-Methoxy-2-phenylessigsaure;(r)-2-Methoxy-2-phenyl-acetic acid;(R)-alpha-methoxy-phenyl acetic acid;AKOS006343439;AKOS015850959;(R)-(-)alpha-methoxyphenylacetic acid;D-(-)-METHOXYPHENYLACETIC ACID;AS-17979;(-)-2-METHOXY-2-PHENYLACETIC ACID;(R)-(-)- alpha -Methoxyphenylacetic acid;CS-0020718;M0830;(-)-.ALPHA.-METHOXYPHENYLACETIC ACID;(R)-(-)-alpha-Methoxyphenylacetic acid, 99%;EN300-128484;A824683;BENZENEACETIC ACID, .ALPHA.-METHOXY-, (.ALPHA.R)-;(R)-(-)-alpha-Methoxyphenylacetic acid, for chiral derivatization, >=99.0%

Chemical Property of (R)-(-)-alpha-Methoxyphenylacetic acid

Chemical Property:

• Appearance/Colour: white fine crystalline powder or needles
• Vapor Pressure: 0.00146mmHg at 25°C
• Melting Point: 66-68 °C(lit.)
• Refractive Index: -147 ° (C=0.5, EtOH)
• Boiling Point: 283.8 °C at 760 mmHg
• PKA: 3.10±0.10(Predicted)
• Flash Point: 116.1 °C
• PSA: 46.53000
• Density: 1.182 g/cm³
• LogP: 1.45870
• Storage Temp.: 2-8°C
• Solubility.: Chloroform, Ethanol, Methanol
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 166.062994177
• Heavy Atom Count: 12
• Complexity: 150

Purity/Quality:

99% ^*data from raw suppliers

(R)-(?)-α-Methoxyphenylacetic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC(C1=CC=CC=C1)C(=O)O
• Isomeric SMILES: CO[C@H](C1=CC=CC=C1)C(=O)O
• Uses: (R)-(-)-α-Methoxyphenylacetic Acid is a useful synthetic intermediate. It is used as a reactant in the synthesis of dopamine receptor agonists. It can also be used to prepare hydroxytriamides as potent γ-secretase inhibitors.

Technology Process of (R)-(-)-alpha-Methoxyphenylacetic acid

There total 60 articles about (R)-(-)-alpha-Methoxyphenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-(methoxy-phenyl-acetyl)-4-phenyl-oxazolidin-2-one → (R)-methoxyphenylacetic acid (3966-32-3)

Guidance literature:

With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water; at 20 ℃; for 12h;

DOI:10.1016/j.tetasy.2007.01.018

Reference yield: 95.0%

(-)-(R)-2-methoxy-2-phenylacetaldehyde (72538-27-3) → (R)-methoxyphenylacetic acid (3966-32-3)

Guidance literature:

With sodium chlorite; sodium dihydrogenphosphate; In water; tert-butyl alcohol;

DOI:10.1016/j.tetasy.2005.05.002

Reference yield: 90.0%

(2S,3R)-3-Methoxy-3-phenyl-1,2-propanediol (121194-48-7) → (R)-methoxyphenylacetic acid (3966-32-3)

Guidance literature:

With sodium periodate; ruthenium trichloride; In tetrachloromethane; water; acetonitrile; for 2h; Ambient temperature;

DOI:10.1055/s-1989-27141

upstream raw materials:

Chloro-phenyl-acetic acid

sodium methylate

(-)-(R)-2-methoxy-2-phenylacetaldehyde

(R)-2-bromo-2-phenylacetic acid

Downstream raw materials:

(R)-(-)-α-methoxyphenylacetyl chloride

(R)-2-Methoxy-2-phenylessigsaeure-4-nitrophenylester

N-<(S)-1-Ethyl-2-propinyl>-(R)-O-methylmandelamid

N-<(S)-1-methyl-2-propynyl>-(R)-O-methylmandelic amide

Refernces

• 1、 -. "(R)- N - [5 - (2 - methoxy - 2 - phenyl-acetyl) - 1, 4, 5, 6 - tetrahydro-pyrrolo [3, 4 - c] pyrazole - 3 - yl] - 4 - (4 - methyl piperazine - 1 - yl) benzamide synthesis method". Paragraph 0056; 0068. . Retrieved 2017/02/17.
• 2、 Bai, Lian-Yang,Zhang, Yu-Ping,Deng, Pu-Hong,Zhang, Yi-Jun,Chen, Jun. "Enantioseparation of typical pesticides using cellulose carbamate stationary phases by capillary liquid chromatography". experimental part. p. 4917 - 4922. Retrieved 2012/10/08.