5-(2-HYDROXYPHENYL)-1H-TETRAZOLE

Base Information

• Chemical Name: 5-(2-HYDROXYPHENYL)-1H-TETRAZOLE
• CAS No.: 51449-77-5
• Molecular Formula: C7H6N4O
• Molecular Weight: 162.151
• Hs Code.: 2933990090
• Mol file: 51449-77-5.mol

Synonyms:2-(1H-Tetrazol-5-yl)phenol;2-(2H-1,2,3,4-Tetrazol-5-yl)phenol;5-(2-Hydroxyphenyl)-2H-tetrazole;5-(2-Hydroxyphenyl)tetrazole;5-(o-Hydroxyphenyl)tetrazole;Phenol, o-tetrazol-5-yl- (6CI);Phenol,2-(1H-tetrazol-5-yl)- (9CI);

Chemical Property of 5-(2-HYDROXYPHENYL)-1H-TETRAZOLE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 230°C
• Refractive Index: 1.668
• Boiling Point: 391.8 °C at 760 mmHg
• PKA: 4.02±0.10(Predicted)
• Flash Point: 190.8 °C
• PSA: 74.69000
• Density: 1.458 g/cm³
• LogP: 0.57230
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-(1H-Tetrazol-5-yl)phenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(2-HYDROXYPHENYL)-1H-TETRAZOLE

There total 14 articles about 5-(2-HYDROXYPHENYL)-1H-TETRAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-Iodophenol (533-58-4) + potassium tetracyanonickelate(II) → 2-(1H-tetrazol-5-yl)phenol (51449-77-5)

Guidance literature:

With sodium azide; sodium phosphate; In N,N-dimethyl-formamide; at 110 ℃; for 5.9h;

DOI:10.1016/j.jorganchem.2018.11.006

Reference yield: 98.0%

salicylonitrile (611-20-1) → 2-(1H-tetrazol-5-yl)phenol (51449-77-5)

Guidance literature:

With hydrogenchloride; sodium azide; water; triethylamine hydrochloride; In toluene; at 95 - 99 ℃; for 6h;

DOI:10.1055/s-1998-2081

Reference yield: 98.0%

2-Iodophenol (533-58-4) + potassium ferrocyanide → 2-(1H-tetrazol-5-yl)phenol (51449-77-5)

Guidance literature:

With sodium azide; potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 6.5h;

DOI:10.1039/c7nj02222k

upstream raw materials:

salicylonitrile

diethyl aluminiumcholoride

salicylaldehyde-oxime

salicylaldehyde

Downstream raw materials:

<(4-hydroxy-3-1H-tetrazol-5-yl)phenyl>ethanone

salicylonitrile

Tropone

ortho-cresol

Refernces

• 1、 Gajurel, Sushmita,Dam, Binoyargha,Bhushan, Mayank,Singh, L. Robindro,Pal, Amarta Kumar. "CuO–NiO bimetallic nanoparticles supported on graphitic carbon nitride with enhanced catalytic performance for the synthesis of 1,2,3-triazoles, bis-1,2,3-triazoles, and tetrazoles in parts per million level". . . Retrieved 2021/12/09.
• 2、 Moradi, Parisa,Hajjami, Maryam. "Magnetization of biochar nanoparticles as a novel support for fabrication of organo nickel as a selective, reusable and magnetic nanocatalyst in organic reactions". . p. 2981 - 2994. Retrieved 2021/02/26.