2-bromo-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile

Base Information

• Chemical Name: 2-bromo-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile
• CAS No.: 113124-08-6
• Molecular Formula: C9H7BrN2
• Mol file: 113124-08-6.mol

Synonyms:

Chemical Property of 2-bromo-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile

Chemical Property:

• Vapor Pressure: 0.000296mmHg at 25°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-bromo-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile

There total 4 articles about 2-bromo-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile (113511-27-6) → 2-bromo-6,7-dihydro-5H-1-pyrindine-3-carbonitrile (113124-08-6)

Guidance literature:

With hydrogen bromide; acetic acid; In water; at 100 ℃; for 8h;

Reference yield: 43.0%

2-oxo-2,5,6,7-tetrahydro-3-cyano-1H-cyclopenta[b]pyridine-3-carbonitrile (108106-97-4) → 2-bromo-6,7-dihydro-5H-1-pyrindine-3-carbonitrile (113124-08-6)

Guidance literature:

With phosphorus tribromide; for 1.5h; Heating;

Reference yield:

2-(hydroxymethylene)cyclopentanone, sodium salt → 2-bromo-6,7-dihydro-5H-1-pyrindine-3-carbonitrile (113124-08-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 42 percent / piperidine acetate / H₂O / 4 h / Heating

2: 43 percent / PBr₃ / 1.5 h / Heating

With phosphorus tribromide; piperdinium acetate; In water;

upstream raw materials:

2-oxo-2,5,6,7-tetrahydro-3-cyano-1H-cyclopenta[b]pyridine-3-carbonitrile

cyclopentanone

2-chloro-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile

Downstream raw materials:

6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile

Refernces

• 1、 Paine, John B.. "A Convenient Synthesis of Nicotinate Esters from 3-Cyanopyridones". . p. 351 - 355. Retrieved 2007/10/02.