Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate

Base Information

• Chemical Name: Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate
• CAS No.: 10128-91-3
• Molecular Formula: C7H7NO3
• Molecular Weight: 153.137
• Hs Code.: 2933399090
• Mol file: 10128-91-3.mol

Synonyms:methyl 2-oxo-1H-pyridine-3-carboxylate;3-Pyridinecarboxylic acid, 1,2-dihydro-2-oxo-, methyl ester;methyl 2-oxo-1,2-dihydropyridine-3-carboxylate;2-Hydroxy nicotinic acid methyl ester;

Chemical Property of Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 115-118 °C
• Refractive Index: 1.518
• Boiling Point: 367.649 °C at 760 mmHg
• PKA: 10.07±0.10(Predicted)
• Flash Point: 176.148 °C
• PSA: 59.16000
• Density: 1.264 g/cm³
• LogP: 0.16150
• Storage Temp.: Refrigerated.

Purity/Quality:

99% ^*data from raw suppliers

Methyl2-hydroxynicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate

There total 16 articles about Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 2-hydroxy-3-carboxypyridine (609-71-2) → methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile (10128-91-3)

Guidance literature:

With sulfuric acid; Heating / reflux;

Reference yield: 90.0%

methanol (67-56-1) + 1,2-dihydro-2-oxonicotinic acid (609-71-2) → methyl 2-hydroxynicotinate (10128-91-3)

Guidance literature:

With thionyl chloride; Ambient temperature;

Reference yield: 84.0%

methanol (67-56-1) + 2-hydroxy-3-carboxypyridine (609-71-2) → methyl 2-hydroxynicotinate (10128-91-3)

Guidance literature:

With sulfuric acid; In toluene; at 20 ℃; for 28h;

upstream raw materials:

methanol

2-hydroxy-3-carboxypyridine

1,2-dihydro-2-oxonicotinic acid

2-fluoronicotinic acid

Downstream raw materials:

methyl 2-hydroxy-5-iodopyridine-3-carboxylate

C₃₃H₂₇NO₁₀

C₃₄H₂₉NO₁₀

methyl 2-(3-nitrophenyl)-3-pyridinecarboxylate

Refernces

• 1、 -. "POLYCYCLIC AMIDES AS UBE2K MODULATORS FOR TREATING CANCER". Paragraph 00150-00152. . Retrieved 2021/07/10.
• 2、 -. "MODIFIED COMPOUND OF ANDROGRAPHOLIDE". Paragraph 0244-0246. . Retrieved 2019/01/04.