1-PYRIDIN-2-YLETHAN-1-ONE OXIME

Base Information

• Chemical Name: 1-PYRIDIN-2-YLETHAN-1-ONE OXIME
• CAS No.: 1758-54-9
• Molecular Formula: C₇H₈N₂O
• Molecular Weight: 136.153
• Hs Code.: 2933399090
• Mol file: 1758-54-9.mol

Synonyms:(2Z)-2-(1-Nitrosoethylidene)-1, 2-dihydropyridine;

Chemical Property of 1-PYRIDIN-2-YLETHAN-1-ONE OXIME

Chemical Property:

• Vapor Pressure: 0.203mmHg at 25°C
• Melting Point: 117 °C
• Refractive Index: 1.55
• Boiling Point: 209.4 °C at 760 mmHg
• Flash Point: 80.5 °C
• PSA: 45.48000
• Density: 1.11 g/cm³
• LogP: 1.27980
• Storage Temp.: 2-8°C
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

98%min ^*data from raw suppliers

1-Pyridin-2-yl-ethanoneoxime ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl-2-pyridyl ketoxime is used as colorimetric reagent for rhenium. Methyl-2-pyridyl ketoxime has been proposed as an analytical reagent for the spectrophotometric determination of copper, iron in alkaline aqueous solution and phenyl-2 pyridyl ketoxime.

Technology Process of 1-PYRIDIN-2-YLETHAN-1-ONE OXIME

There total 5 articles about 1-PYRIDIN-2-YLETHAN-1-ONE OXIME which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.7%

2-acetylpyridine (1122-62-9) → 1-pyridin-2-yl-ethanone oxime (1758-54-9,79462-42-3,81563-77-1)

Guidance literature:

With hydroxylamine hydrochloride; sodium hydrogencarbonate; In ethanol; water; at 0 - 20 ℃; for 3h; Reagent/catalyst;

Reference yield: 73.0%

2-ethynylpyridine (1945-84-2) → 2-(pyridin-2-yl)acetaldehyde oxime (736102-09-3) + 1-pyridin-2-yl-ethanone oxime (1758-54-9,79462-42-3,81563-77-1)

Guidance literature:

With hydroxylamine; In 1,4-dioxane; water; at 113 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1021/ja806300r

Reference yield: 59.0%

2-vinylpyridine (100-69-6,25014-15-7,27476-03-5,329041-71-6) → 1-pyridin-2-yl-ethanone oxime (1758-54-9,79462-42-3,81563-77-1)

Guidance literature:

With sodium tetrahydroborate; tert.-butylnitrite; iron(II) phthalocyanine; hydrogen; In ethanol; at 20 ℃; for 3h; under 7500.75 Torr;

DOI:10.1039/b900326f

upstream raw materials:

2-acetylpyridine

2-ethynylpyridine

2-vinylpyridine

Downstream raw materials:

C₁₄H₁₄N₂O₃S

Re(NC₆H₄Cl)Cl₂(P(C₆H₅)3)(NC₅H₄C(CH₃)NO)

Re(NC₆H₅)Cl₂(P(C₆H₅)3)(NC₅H₄C(CH₃)NO)

N-[1-(pyridin-2-yl)ethylidene]diphenylphosphinic amide

Refernces

• 1、 Svobodova, Eva,Cibulka, Radek,Hampl, Frantisek,Smidrkal, Jan,Liska, Frantisek. "Metal ion transport through bulk liquid membrane mediated by cationic ligand surfactants". . p. 441 - 465. Retrieved 2005.
• 2、 Kuilya, Hemrupa,Alam, Noohul,Sarma, Debajit,Choudhury, Diganta,Kalita, Apurba. "Ligand assisted electrocatalytic water oxidation by a copper(ii) complex in neutral phosphate buffer". . p. 5483 - 5486. Retrieved 2019.
• 3、 -. "1-methyl-[1,5-a]-pyridinium imidazole-3-nitrile and chemical synthesis method thereof". Paragraph 0027-0029; 0040-0042; 0053-0055. . Retrieved 2020/01/25.
• 4、 Miao, Chun-Bao,Zheng, An-Qi,Zhou, Li-Jin,Lyu, Xinyu,Yang, Hai-Tao. "Copper-Catalyzed Annulation of Oxime Acetates with α-Amino Acid Ester Derivatives: Synthesis of 3-Sulfonamido/Imino 4-Pyrrolin-2-ones". supporting information. p. 3381 - 3385. Retrieved 2020/04/21.