2-Chloro-4-methyl-6-nitro-quinoline

Base Information

• Chemical Name: 2-Chloro-4-methyl-6-nitro-quinoline
• CAS No.: 54965-59-2
• Molecular Formula: C10H7ClN2O2
• Molecular Weight: 222.631
• Hs Code.: 2933499090
• Mol file: 54965-59-2.mol

Synonyms:Quinoline, 2-chloro-4-methyl-6-nitro-;

Chemical Property of 2-Chloro-4-methyl-6-nitro-quinoline

Chemical Property:

• Vapor Pressure: 1.02E-05mmHg at 25°C
• Melting Point: 382.7 °C at 760 mmHg
• Refractive Index: 1.668
• Boiling Point: 185.3 °C
• PKA: -0.79±0.50(Predicted)
• Flash Point: 185.3°C
• PSA: 58.71000
• Density: 1.419 g/cm³
• LogP: 3.62800

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-4-methyl-6-nitroquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-4-methyl-6-nitro-quinoline

There total 10 articles about 2-Chloro-4-methyl-6-nitro-quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-methyl-6-nitro-quinolin-2-ol (90771-17-8) → 2-chloro-4-methyl-6-nitroquinoline (54965-59-2)

Guidance literature:

With trichlorophosphate; at 65 ℃; for 6h;

DOI:10.1016/j.ejmech.2017.07.080

Reference yield: 70.0%

4-methyl-6-nitroquinolin-2(1H)-one (90771-17-8) → 2-chloro-4-methyl-6-nitroquinoline (54965-59-2)

Guidance literature:

With trichlorophosphate; at 100 ℃;

DOI:10.1016/S0040-4020(01)89775-1

Reference yield: 65.0%

2-isopropenyl-4-nitro-phenylamine + trichloromethyl chloroformate (503-38-8) → 2-chloro-4-methyl-6-nitroquinoline (54965-59-2)

Guidance literature:

In acetonitrile; at 130 ℃; for 10h;

DOI:10.1021/jo016196i

upstream raw materials:

2-chloro-4-methylquinoline

4-methyl-6-nitro-quinolin-2-ol

4-methyl-6-nitroquinolin-2(1H)-one

sulfuric acid

Downstream raw materials:

4-methyl-6-nitro-2-piperazino-quinoline

(4-methyl-6-nitro-[2]quinolyl)-(2-morpholino-ethyl)-amine

(4-chloro-phenyl)-(4-methyl-6-nitro-[2]quinolyl)-amine

6-amino-2-chloro-4-methylquinoline

Refernces

• 1、 Jiang, Fen,Guo, An-ping,Xu, Jia-cheng,Wang, Hui-Jie,Mo, Xiao-fei,You, Qi-Dong,Xu, Xiao-Li. "Identification and optimization of novel 6-acylamino-2-aminoquinolines as potent Hsp90 C-terminal inhibitors". . p. 1 - 14. Retrieved 2017/10/16.
• 2、 -. "SUBSTITUTED QUINOLINES AS MCR MODULATORS". Page/Page column 45. . Retrieved 2008/06/13.