2-Amino-3-(1,2-dihydro-2-oxoquinoline-4-yl)propanoic acid

Base Information

• Chemical Name: 2-Amino-3-(1,2-dihydro-2-oxoquinoline-4-yl)propanoic acid
• CAS No.: 5162-90-3
• Molecular Formula: C12H12 N2 O3
• Molecular Weight: 232.239
• Hs Code.: 2933499090
• Mol file: 5162-90-3.mol

Synonyms:4-Quinolinealanine,1,2-dihydro-2-oxo- (7CI,8CI);a-Amino-b-[4-(1,2-dihydro-2-oxoquinoline)]propionicacid;

Chemical Property of 2-Amino-3-(1,2-dihydro-2-oxoquinoline-4-yl)propanoic acid

Chemical Property:

• Appearance/Colour: white or almost white crystalline powder
• Vapor Pressure: 2.76E-07mmHg at 25°C
• Melting Point: 265~266 °C
• Refractive Index: 1.562
• Boiling Point: 420.7 °C at 760 mmHg
• PKA: 2.22±0.10(Predicted)
• Flash Point: 208.2 °C
• PSA: 96.18000
• Density: 1.343 g/cm³
• LogP: 1.18280
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

α-Amino-β-[4-(1,2-dihydro-2-oxoquinoline)]propionicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: α-Amino-β-[4-(1,2-dihydro-2-oxoquinoline)]propionic Acid can be used to predict the activity of antimicrobial peptides with amino acid topological information.

Technology Process of 2-Amino-3-(1,2-dihydro-2-oxoquinoline-4-yl)propanoic acid

There total 4 articles about 2-Amino-3-(1,2-dihydro-2-oxoquinoline-4-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.2%

2-acetylamino-2-(ethoxycarbonyl)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propionic acid ethyl ester (4900-38-3) → 2‐amino‐3‐[2(1H)‐quinolinon‐4‐yl]propionic acid (5162-90-3)

Guidance literature:

With water; hydrogenchloride; acetic acid; for 6h; Heating / reflux;

Reference yield: 35.0%

2-quinolone (59-31-4,70254-42-1,493-62-9) + aspartic Acid (617-45-8,25608-40-6,27881-03-4,32505-46-7,52526-39-3) → 2‐amino‐3‐[2(1H)‐quinolinon‐4‐yl]propionic acid (5162-90-3)

Guidance literature:

With dipotassium peroxodisulfate; silver nitrate; In water; acetonitrile; at 60 ℃; for 3h; Temperature;

Reference yield:

→ 2‐amino‐3‐[2(1H)‐quinolinon‐4‐yl]propionic acid (5162-90-3)

Guidance literature:

Diethyl-acetamido-(2-hydroxy-4-chinolylmethyl)-malonat (XXI), 1. wss. KOH (Δ), 2. wss. HCl (Δ);

upstream raw materials:

2-acetylamino-2-(ethoxycarbonyl)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propionic acid ethyl ester

2-quinolone

aspartic Acid

Downstream raw materials:

rebamipide

Refernces

• 1、 -. "PROCESS FOR PRODUCTION OF CARBOSTYRIL COMPOUND". Page/Page column 11-12. . Retrieved 2008/06/13.