Trifenmorph

Base Information

• Chemical Name: Trifenmorph
• CAS No.: 1420-06-0
• Molecular Formula: C23H23 N O
• Molecular Weight: 329.442
• Hs Code.: 29349990
• European Community (EC) Number: 215-812-2
• UNII: H1IL51K9CW
• DSSTox Substance ID: DTXSID6042492
• Nikkaji Number: J7.484E
• Wikidata: Q27155848
• ChEMBL ID: CHEMBL2086832
• Mol file: 1420-06-0.mol

Synonyms:Frescon;N-tritylmorpholine;trifenmorph;WL 8008

Chemical Property of Trifenmorph

Chemical Property:

• Vapor Pressure: 1.14E-07mmHg at 25°C
• Melting Point: 174-176°, resolidifies and melts again at 185-187°
• Refractive Index: 1.5614 (estimate)
• Boiling Point: 432.1°Cat760mmHg
• PKA: 4.58±0.10(Predicted)
• Flash Point: 126.5°C
• PSA: 12.47000
• Density: 1.12g/cm³
• LogP: 4.24860
• Water Solubility.: 20ug/L(20 oC)
• XLogP3: 4.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 329.177964357
• Heavy Atom Count: 25
• Complexity: 339

Purity/Quality:

98%min ^*data from raw suppliers

4-TRITYL-MORPHOLINE AldrichCPR ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn,N
• Statements: 22-50/53
• Safety Statements: 60-61

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Pesticides -> Molluscicides
• Canonical SMILES: C1COCCN1C(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4
• Uses: As molluscicide (against snails carrying bilharzia flukes).

Technology Process of Trifenmorph

There total 8 articles about Trifenmorph which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

morpholine (110-91-8,99108-56-2) + trityl chloride (76-83-5) → trifenmorph (1420-06-0)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 3h;

DOI:10.1039/c3cc45082a

Reference yield: 44.0%

morpholine (110-91-8,99108-56-2) + 4-dimethylamino-1-N-(triphenylmethyl)pyridinium chloride (78646-25-0) → trifenmorph (1420-06-0)

Guidance literature:

With 5-(3-methoxy-3-methylbut-1-yn-1-yl)-1,3-bis(1-(3,5-bis(trifluoromethyl)-phenyl)-1H-1,2,3-triazol-4-yl)benzene; In tetrahydrofuran; at 45 ℃; for 72h;

DOI:10.1002/chem.201203360

Reference yield:

triphenylmethyl alcohol (76-84-6) → trifenmorph (1420-06-0)

Guidance literature:

Multi-step reaction with 2 steps

1: acetyl chloride / benzene / Reflux

2: triethylamine / dichloromethane / 18 h / 25 °C

With triethylamine; acetyl chloride; In dichloromethane; benzene;

DOI:10.1016/j.bmcl.2012.08.009

upstream raw materials:

morpholine

triphenylmethyl 4-cyanophenyl ether

trityl chloride

triphenylmethyl alcohol

Refernces

• 1、 Paul, Sibasish,Jana, Santanu,Bhadra, Jhuma,Sinha, Surajit. "Photophysical studies and submicron ring formation of morpholino U-nucleoside monomers". . p. 11278 - 11280. Retrieved 2013.
• 2、 -. "Skin care". Paragraph 0113-0114. . Retrieved 2020/10/19.