Unii-T4np8G3K6q

Base Information

• Chemical Name: Unii-T4np8G3K6q
• CAS No.: 195533-53-0
• Molecular Formula: C13H7F6NO3S
• Molecular Weight: 371.26
• Mol file: 195533-53-0.mol

Synonyms:T67;2,3,4,5,6-pentafluoro-N-(3-fluoro-4-methoxyphenyl)benzene sulfonamide;2-fluoro-1-methoxy-4-pentafluorophenyl-sulfonamidobenzene;Batabulin [USAN];N-(3-fluoro-4-methoxyphenyl)-2,3,4,5,6-pentafluorobenzenesulfonamide;Batabulin;Batabulin (USAN/INN);Batabulin [INN];

Chemical Property of Unii-T4np8G3K6q

Chemical Property:

• Vapor Pressure: 1.03E-06mmHg at 25°C
• Boiling Point: 403.3°Cat760mmHg
• Flash Point: 197.7°C
• PSA: 63.78000
• Density: 1.629g/cm³
• LogP: 4.48440

Purity/Quality:

98% ^*data from raw suppliers

Batabulin 99.91% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Treatment of various refractory cancers, including hepatocellular carcinoma, breast, colon and non-small cell lung cancer.

Technology Process of Unii-T4np8G3K6q

There total 2 articles about Unii-T4np8G3K6q which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

pentafluorobenzenesulonyl chloride (832-53-1) + 3-fluoro-4-methoxyaniline (366-99-4) → 2-fluoro-1-methoxy-4-pentafluorophenyl-sulfonamidobenzene (195533-53-0)

Guidance literature:

In methanol;

DOI:10.1016/j.bmcl.2003.12.061

Reference yield:

→ 2-fluoro-1-methoxy-4-pentafluorophenyl-sulfonamidobenzene (195533-53-0)

Guidance literature:

Reference yield: 43.0%

2-fluoro-1-methoxy-4-pentafluorophenyl-sulfonamidobenzene (195533-53-0) → N-(3-fluoro-4-hydroxyphenyl)-2,3,4,5,6-pentafluorobenzenesulfonamide (683274-41-1)

Guidance literature:

With boron tribromide; In dichloromethane;

DOI:10.1016/j.bmcl.2003.12.061

upstream raw materials:

pentafluorobenzenesulonyl chloride

3-fluoro-4-methoxyaniline

Downstream raw materials:

N-(3-fluoro-4-hydroxyphenyl)-2,3,4,5,6-pentafluorobenzenesulfonamide

Refernces

• 1、 Fei, Xiangshu,Zheng, Qi-Huang,Wang, Ji-Quan,Stone, K. Lee,Martinez, Tanya D.,Miller, Kathy D.,Sledge, George W.,Hutchins, Gary D.. "Synthesis, biodistribution and micro-PET imaging of radiolabeled antimitotic agent T138067 analogues". . p. 1247 - 1251. Retrieved 2007/10/03.
• 2、 -. "Pentafluorobenzenesulfonamides and analogs". . . Retrieved 2008/06/13.