2-chloro-6-phenyl-4-(trifluoromethyl)nicotinonitrile

Base Information

• Chemical Name: 2-chloro-6-phenyl-4-(trifluoromethyl)nicotinonitrile
• CAS No.: 114084-91-2
• Molecular Formula: C13H6ClF3N2
• Molecular Weight: 282.64800
• Mol file: 114084-91-2.mol

Synonyms:4-trifluoromethyl-6-phenyl-2-chloro-3-cyanopyridine;2-Chloro-3-cyano-6-phenyl-4-trifluoromethylpyridine;2-chloro-3-cyano-4-trifluoromethyl-6-phenylpyridine;

Chemical Property of 2-chloro-6-phenyl-4-(trifluoromethyl)nicotinonitrile

Chemical Property:

• PSA: 36.68000
• LogP: 4.29248

Purity/Quality:

2-Chloro-6-phenyl-4-(trifluoromethyl)-nicotinonitrile 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-chloro-6-phenyl-4-(trifluoromethyl)nicotinonitrile

There total 1 articles about 2-chloro-6-phenyl-4-(trifluoromethyl)nicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-oxo-6-phenyl-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile (3335-44-2) → 4-trifluoromethyl-6-phenyl-2-chloro-3-cyanopyridine (114084-91-2)

Guidance literature:

With triethylamine; trichlorophosphate; In N,N-dimethyl-formamide; at 90 ℃; for 8h;

DOI:10.1002/jhet.1511

Reference yield: 94.0%

4-trifluoromethyl-6-phenyl-2-chloro-3-cyanopyridine (114084-91-2) + benzylamine (100-46-9) → 2-(benzylamino)-6-phenyl-4-(trifluoromethyl)nicotinonitrile (114084-94-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 2h;

DOI:10.1002/jhet.1511

Reference yield: 91.0%

piperidine (110-89-4) + 4-trifluoromethyl-6-phenyl-2-chloro-3-cyanopyridine (114084-91-2) → 6'-Phenyl-4'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-carbonitrile (114084-98-9)

Guidance literature:

In 1,4-dioxane; for 1h; Heating;

DOI:10.1007/BF00475366

upstream raw materials:

2-oxo-6-phenyl-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile

Downstream raw materials:

6'-Phenyl-4'-trifluoromethyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-carbonitrile

2-Morpholin-4-yl-6-phenyl-4-trifluoromethyl-nicotinonitrile

2-thioxo-6-phenyl-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile

2-azido-4-trifluoromethyl-6-phenyl-3-cyanopyridine

Refernces

• 1、 Guttsait, A. V.,Belyakov, S. V.,Mishnev, A. F.,Bleidelis, Ya. Ya.,Gudrinietse, E. Yu.. "SYNTHESIS, PROPERTIES, AND X-RAY DIFFRACTION STUDY OF 4-TRIFLUOROMETHYL-6-PHENYL-2-CHLORO-3-CYANOPYRIDINE". . p. 986 - 989. Retrieved 2007/10/02.