Guanine hydrochloride

Base Information

• Chemical Name: Guanine hydrochloride
• CAS No.: 635-39-2
• Molecular Formula: C5H6ClN5O
• Molecular Weight: 187.589
• Hs Code.: 29339900
• Mol file: 635-39-2.mol

Synonyms:6H-Purin-6-one,2-amino-1,7-dihydro-, monohydrochloride (9CI);Guanine, monohydrochloride(8CI);Guaninium chloride;

Chemical Property of Guanine hydrochloride

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Vapor Pressure: 0.000375mmHg at 25°C
• Melting Point: ≥ 300 °C
• Refractive Index: 2.047
• Boiling Point: 591.4 °C at 760 mmHg
• Flash Point: 311.4 °C
• PSA: 100.45000
• Density: 2.19g/cm3
• LogP: 0.61160
• Storage Temp.: 2-8°C
• Solubility.: DMSO (Sparingly, Heated), Methanol (Slightly)
• Water Solubility.: Slightly soluble in water

Purity/Quality:

99% ^*data from raw suppliers

Guanine Hydrochloride 99+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Guanine hydrochloride is one of the strongest denaturant. It is mainly used in protein purification and protein folding studies. It is a nucleobase used in biochemical research.

Technology Process of Guanine hydrochloride

There total 1 articles about Guanine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ Guanin (635-39-2)

Guidance literature:

1. Guanidin, 4(5)-Aminoimidazol-5(4)-carboxamid, 2. HCl;

Reference yield: 25.0%

5-(4-tert-butylphenyl)-1-(4-cyclopentyloxyphenyl)indole-2-carboxylic acid ethyl ester (902169-27-1) + Guanine hydrochloride (635-39-2) → N-[5-(4-tert-butylphenyl)-1-(4-cyclopentyloxyphenyl)indole-2-carbonyl]-guanidine

Guidance literature:

With sodium methylate; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

Guanine hydrochloride (635-39-2) → 2-amino-7-(2-hydroxy-2-phenylethyl)purin-6-one

Guidance literature:

Multi-step reaction with 4 steps

1: 43 percent / aq. HCl / 24 h / 45 °C

2: 37 percent / K₂CO₃ / dimethylformamide / 60 °C

3: 91 percent / aq. NaOH

4: 36 percent / ZnCl₂; poly(methylhydrosiloxane) / [Pd(PPh₃)4] / dimethylformamide / 3 h / 60 °C

With hydrogenchloride; sodium hydroxide; potassium carbonate; zinc(II) chloride; poly(methylhydrosiloxane); tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide;

DOI:10.1002/ejoc.200300811

Downstream raw materials:

C₁₁H₉N₆⁽¹⁵⁾NO

(S)-2-[4-(2-Amino-6-oxo-6,9-dihydro-1H-purin-8-ylazo)-benzoylamino]-pentanedioic acid

4-(2-Amino-6-oxo-6,9-dihydro-1H-purin-8-ylazo)-benzoic acid

4-(2-Amino-6-oxo-6,9-dihydro-1H-purin-8-ylazo)-benzenesulfonamide