2-(1-phenyl-1H-pyrazol-4-yl)-1,3-thiazole-4-carboxylic acid

Base Information

• Chemical Name: 2-(1-phenyl-1H-pyrazol-4-yl)-1,3-thiazole-4-carboxylic acid
• CAS No.: 137576-90-0
• Molecular Formula: C13H9N3O2S
• Molecular Weight: 271.299
• European Community (EC) Number: 899-374-3
• Nikkaji Number: J433.705K
• Mol file: 137576-90-0.mol

Synonyms:2-(1-phenyl-1H-pyrazol-4-yl)-1,3-thiazole-4-carboxylic acid;137576-90-0;2-(1-PHENYLPYRAZOL-4-YL)-1,3-THIAZOLE-4-CARBOXYLIC ACID;SCHEMBL25208266;AKOS008122086;EN300-61903;G44340;Z234895733;2-(1-phenyl-1H-pyrazol-4-yl)-1,3-thiazole-4-carboxylicacid

Chemical Property of 2-(1-phenyl-1H-pyrazol-4-yl)-1,3-thiazole-4-carboxylic acid

Chemical Property:

• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 271.04154771
• Heavy Atom Count: 19
• Complexity: 336

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)N2C=C(C=N2)C3=NC(=CS3)C(=O)O

Technology Process of 2-(1-phenyl-1H-pyrazol-4-yl)-1,3-thiazole-4-carboxylic acid

There total 4 articles about 2-(1-phenyl-1H-pyrazol-4-yl)-1,3-thiazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

Ethyl 2-<4-(1-phenylpyrazolyl)>-4-thiazolylcarboxylate (137576-89-7) → 2-<4-(1-Phenylpyrazolyl)>-4-thiazolylcarboxylic acid (137576-90-0)

Guidance literature:

With sodium hydroxide; In ethanol; for 0.5h; Heating;

DOI:10.1002/jhet.5570280625

Reference yield:

1-phenyl-1H-pyrazole-4-carbonitrile (709-04-6) → 2-<4-(1-Phenylpyrazolyl)>-4-thiazolylcarboxylic acid (137576-90-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 71 percent / O,O-diethyldithiophosphoric acid, water / 80 °C

2: 86 percent / ethanol / 0.5 h / Heating

3: 91 percent / 2 N aq. sodium hydroxide / ethanol / 0.5 h / Heating

With sodium hydroxide; water; O,O-Diethyl hydrogen phosphorodithioate; In ethanol;

DOI:10.1002/jhet.5570280625

Reference yield:

5-Amino-4-cyano-1-phenylpyrazole (5334-43-0) → 2-<4-(1-Phenylpyrazolyl)>-4-thiazolylcarboxylic acid (137576-90-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 51 percent / isopentylnitrite / tetrahydrofuran / Heating

2: 71 percent / O,O-diethyldithiophosphoric acid, water / 80 °C

3: 86 percent / ethanol / 0.5 h / Heating

4: 91 percent / 2 N aq. sodium hydroxide / ethanol / 0.5 h / Heating

With sodium hydroxide; water; O,O-Diethyl hydrogen phosphorodithioate; isopentyl nitrite; In tetrahydrofuran; ethanol;

DOI:10.1002/jhet.5570280625

upstream raw materials:

Ethyl 2-<4-(1-phenylpyrazolyl)>-4-thiazolylcarboxylate

1-phenyl-1H-pyrazole-4-carbonitrile

5-Amino-4-cyano-1-phenylpyrazole

1-Phenyl-4-pyrazolethiocarboxamide

Refernces