Pyridine, 3-((2S)-1-methyl-2-pyrrolidinyl)-, (2R,3R)-2,3-dihydroxybutanedioate

Base Information

• Chemical Name: Pyridine, 3-((2S)-1-methyl-2-pyrrolidinyl)-, (2R,3R)-2,3-dihydroxybutanedioate
• CAS No.: 3275-73-8
• Molecular Formula: 2C₄H₆O₆*C₁₀H₁₄N₂
• Molecular Weight: 462.411
• Mol file: 3275-73-8.mol

Synonyms:3275-73-8;Pyridine, 3-((2S)-1-methyl-2-pyrrolidinyl)-, (2R,3R)-2,3-dihydroxybutanedioate;Pyridine, 3-[(2S)-1-methyl-2-pyrrolidinyl]-, (2R,3R)-2,3-dihydroxybutanedioate;3-((2S)-1-Methyl-2-pyrrolidinyl)pyridine (2R,3R)-2,3-dihydroxybutanedioate;Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-, (R-(R*,R*))-2,3-dihydroxybutanedioate

Chemical Property of Pyridine, 3-((2S)-1-methyl-2-pyrrolidinyl)-, (2R,3R)-2,3-dihydroxybutanedioate

Chemical Property:

• Vapor Pressure: 0.0303mmHg at 25°C
• Boiling Point: 244.4°Cat760mmHg
• Flash Point: 101.7°C
• Density: g/cm³
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 4
• Exact Mass: 312.13213636
• Heavy Atom Count: 22
• Complexity: 281

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CN1CCCC1C2=CN=CC=C2.C(C(C(=O)O)O)(C(=O)O)O
• Isomeric SMILES: CN1CCC[C@H]1C2=CN=CC=C2.[C@H]([C@@H](C(=O)O)O)(C(=O)O)O

Technology Process of Pyridine, 3-((2S)-1-methyl-2-pyrrolidinyl)-, (2R,3R)-2,3-dihydroxybutanedioate

There total 1 articles about Pyridine, 3-((2S)-1-methyl-2-pyrrolidinyl)-, (2R,3R)-2,3-dihydroxybutanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + L-(+)-tartaric acid (87-69-4,133-37-9,147-71-7,147-73-9,526-83-0,138508-61-9) + (+)-nornicotine (7076-23-5,13450-58-3) → (+)-Nicotine bitartrate (65-31-6,1421-32-5,3275-73-8,6550-19-2,50603-04-8,50791-88-3,50915-69-0,51385-03-6,51385-04-7,54661-91-5,129721-88-6,2624-48-8)

Guidance literature:

With sodium cyanoborohydride; Yield given. Multistep reaction; 1.) aq. MeOH, 15 min, 2.) aq. EtOH;

DOI:10.1002/jps.2600770508

Reference yield: 85.0%

1-bromo-butane (109-65-9) + (S)-(-)-nicotine di-L-tartrate (65-31-6,1421-32-5,3275-73-8,6550-19-2,50603-04-8,50791-88-3,50915-69-0,51385-03-6,51385-04-7,54661-91-5,129721-88-6,2624-48-8) → 2Br(1-)*C18H32N2(2+)

Guidance literature:

In methanol; for 4h; Reflux;

DOI:10.1080/00397910903161801

upstream raw materials:

formaldehyd

L-(+)-tartaric acid

(+)-nornicotine

Refernces