1,4-bis(trifluoromethyl)benzene,1,4-bis(trifluoromethyl)cyclohexane,chromium

Base Information

• Chemical Name: 1,4-bis(trifluoromethyl)benzene,1,4-bis(trifluoromethyl)cyclohexane,chromium
• CAS No.: 7235-25-8
• Molecular Formula: C10H10 O3
• Molecular Weight: 480.2149
• Mol file: 7235-25-8.mol

Synonyms:1-Indanone,2-hydroxy-5-methoxy- (7CI,8CI); 2-Hydroxy-5-methoxy-1-indanone

Chemical Property of 1,4-bis(trifluoromethyl)benzene,1,4-bis(trifluoromethyl)cyclohexane,chromium

Chemical Property:

• Vapor Pressure: 22.1mmHg at 25°C
• Boiling Point: 116°Cat760mmHg
• Flash Point: 21.7°C
• Density: g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4-bis(trifluoromethyl)benzene,1,4-bis(trifluoromethyl)cyclohexane,chromium

There total 5 articles about 1,4-bis(trifluoromethyl)benzene,1,4-bis(trifluoromethyl)cyclohexane,chromium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C12H16O4 → 2-hydroxy-5-methoxy-2,3-dihydro-1H-inden-1-one (7235-25-8)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/acs.orglett.7b02577

Reference yield:

5-methoxy-1-indanone (5111-70-6) → 2-hydroxy-5-methoxy-2,3-dihydro-1H-inden-1-one (7235-25-8)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic anhydride; glacial acetic acid / Heating

2: potassium carbonate / methanol; H₂O

With acetic anhydride; potassium carbonate; acetic acid; In methanol; water;

DOI:10.1023/A:1024226029750

Reference yield:

(5-Methoxy-3H-inden-1-yloxy)-trimethyl-silane (192194-99-3) → 2-hydroxy-5-methoxy-2,3-dihydro-1H-inden-1-one (7235-25-8)

Guidance literature:

With HOF* CH₃CN; sodium fluoride; In chloroform; water; acetonitrile; Yield given; 3-4 min;

DOI:10.1021/jo972088d

upstream raw materials:

(5-Methoxy-3H-inden-1-yloxy)-trimethyl-silane

2,3-dihydro-5-methoxy-1-oxo-1H-inden-2-yl acetate

5-methoxy-1-indanone

Refernces

• 1、 Cooper, W. John,Smith, Tyler N.,Barker, Andrea K.,Webb, Jason A.,Valente, Edward J.. "Pseudoacids. III: Formation and structures of new cyclic oxocarboxylic acids". . p. 375 - 384. Retrieved 2007/10/03.