[1-(3,4-Dimethoxyphenyl)-6,7-dimethoxy-1,2,3,4-tetrahydronaphthalene-2,3-diyl]dimethanol

Base Information

• Chemical Name: [1-(3,4-Dimethoxyphenyl)-6,7-dimethoxy-1,2,3,4-tetrahydronaphthalene-2,3-diyl]dimethanol
• CAS No.: 4676-53-3
• Molecular Formula: C22H28 O6
• Molecular Weight: 388.461
• NSC Number: 404538,36566
• DSSTox Substance ID: DTXSID30284290
• Wikidata: Q82019176
• Mol file: 4676-53-3.mol

Synonyms:4676-53-3;[1-(3,4-dimethoxyphenyl)-6,7-dimethoxy-1,2,3,4-tetrahydronaphthalene-2,3-diyl]dimethanol;NSC36566;DTXSID30284290;NSC-36566;NSC404538;NSC-404538

Chemical Property of [1-(3,4-Dimethoxyphenyl)-6,7-dimethoxy-1,2,3,4-tetrahydronaphthalene-2,3-diyl]dimethanol

Chemical Property:

• Vapor Pressure: 1.33E-12mmHg at 25°C
• Boiling Point: 542.5°Cat760mmHg
• Flash Point: 281.9°C
• Density: 1.164g/cm³
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 7
• Exact Mass: 388.18858861
• Heavy Atom Count: 28
• Complexity: 474

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)C2C(C(CC3=CC(=C(C=C23)OC)OC)CO)CO)OC

Technology Process of [1-(3,4-Dimethoxyphenyl)-6,7-dimethoxy-1,2,3,4-tetrahydronaphthalene-2,3-diyl]dimethanol

There total 5 articles about [1-(3,4-Dimethoxyphenyl)-6,7-dimethoxy-1,2,3,4-tetrahydronaphthalene-2,3-diyl]dimethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

lariciresinol (486-29-3,83327-19-9,105367-81-5,27003-73-2) → optically inactive 6,7-dimethoxy-2,3-bis-hydroxymethyl-1-(3,4-dimethoxy-phenyl)-tetralin (4676-53-3)

Guidance literature:

dextrorotatory substance; bei der Methylierung;

DOI:10.1039/jr9370000384

Reference yield:

isolariciresinol (5234-71-9,6753-57-7) + dimethyl sulfate (77-78-1) → optically inactive 6,7-dimethoxy-2,3-bis-hydroxymethyl-1-(3,4-dimethoxy-phenyl)-tetralin (4676-53-3)

Guidance literature:

With alkaline solution; dextrorotatory substance;

DOI:10.1039/jr9370000384

Reference yield:

7-acetoxy-1-(4-acetoxy-3-methoxy-phenyl)-2,3-bis-acetoxymethyl-6-methoxy-1,2,3,4-tetrahydro-naphthalene (5502-30-7,67560-70-7,110201-76-8) → optically inactive 6,7-dimethoxy-2,3-bis-hydroxymethyl-1-(3,4-dimethoxy-phenyl)-tetralin (4676-53-3)

Guidance literature:

Multi-step reaction with 2 steps

1: alcoholic KOH-solution

2: alkaline solution

With potassium hydroxide; alkaline solution;

DOI:10.1039/jr9370000384

upstream raw materials:

ethanol

isolariciresinol

dimethyl sulfate

lariciresinol

Downstream raw materials:

4-(3,4-dimethoxy-phenyl)-6,7-dimethoxy-1,3,3a,4,9,9a-hexahydro-naphtho[2,3-c]furan