trans-4-Isopropylcyclohexane carboxylic acid

Base Information

• Chemical Name: trans-4-Isopropylcyclohexane carboxylic acid
• CAS No.: 7077-05-6
• Molecular Formula: C10H18O2
• Molecular Weight: 170.252
• Hs Code.: 2916209090
• Mol file: 7077-05-6.mol

Synonyms:trans-4-Isopropylcyclohexane carboxylic acid;Cyclohexanecarboxylic acid, 4-isopropyl-, trans-;

Chemical Property of trans-4-Isopropylcyclohexane carboxylic acid

Chemical Property:

• Appearance/Colour: White crystalline powder
• Melting Point: 95 °C
• Boiling Point: 263.8 °C at 760 mmHg
• PKA: 4.91±0.10(Predicted)
• Flash Point: 126.9 °C
• PSA: 37.30000
• Density: 0.996 g/cm³
• LogP: 2.53340
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

trans-4-Isopropylcyclohexanecarboxylic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: trans-4-Isopropylcyclohexane carboxylic acid is an intermediate used in the process for the preparation of Nateglinide (N379375), a novel D-phenylalanine-derivative hypoglycemic agent. trans-4-Isopropylcyclohexanecarboxylic acid is an intermediate used in the process for the preparation of Nateglinide (N379375), a novel D-phenylalanine-derivative hypoglycemic agent. Nateglinide USP Related Compound A.

Technology Process of trans-4-Isopropylcyclohexane carboxylic acid

There total 7 articles about trans-4-Isopropylcyclohexane carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.4%

→ trans-4-isopropylcyclohexane-1-carboxylic acid (7077-05-6) + 4-isopropyl cyclohexane carboxylic acid (62067-45-2)

Guidance literature:

Reference yield:

p-isopropylbenzoic acid (536-66-3) → trans-4-isopropylcyclohexane-1-carboxylic acid (7077-05-6) + (1r,4s)-4-isopropylcyclohexanecarboxylic acid (7084-93-7)

Guidance literature:

With sodium hydroxide; nickel; at 195 ℃; under 73550.8 Torr; Hydrogenation;

DOI:10.1039/jr9390001245

Reference yield:

(4S)-phellandric acid (135355-08-7) → trans-4-isopropylcyclohexane-1-carboxylic acid (7077-05-6)

Guidance literature:

With sodium hydroxide; nickel; at 120 ℃; under 69873.3 Torr; Hydrogenation;

DOI:10.1039/jr9400000808

upstream raw materials:

p-isopropylbenzoic acid

(4S)-phellandric acid

p-menthan-7-oic acid methyl ester

1-methyl-4-nitrosobenzene

Downstream raw materials:

trans-4-isopropylcyclohexylcarboxylic acid N-hydroxysuccinimide ester

C₁₇H₂₄O₄S

trans-1-acetyl-4-isopropylcyclohexane

Refernces

• 1、 Miyamura, Hiroyuki,Suzuki, Aya,Yasukawa, Tomohiro,Kobayashi, Shu. "Polysilane-Immobilized Rh-Pt Bimetallic Nanoparticles as Powerful Arene Hydrogenation Catalysts: Synthesis, Reactions under Batch and Flow Conditions and Reaction Mechanism". supporting information. p. 11325 - 11334. Retrieved 2018/09/06.
• 2、 Koenigsberger, Kurt,Luna, Hector,Prasad, Kapa,Repic, Oljan,Blacklock, Thomas J.. "Separation of cis/trans-cyclohexanecarboxylates by enzymatic hydrolysis: Preference for diequatorial isomers". . p. 9029 - 9032. Retrieved 2007/10/03.