5-bromo-2,3-dihydro-1H-indene

Base Information

• Chemical Name: 5-bromo-2,3-dihydro-1H-indene
• CAS No.: 6134-54-9
• Molecular Formula: C9H9 Br
• Molecular Weight: 197.074
• Hs Code.: 2903999090
• European Community (EC) Number: 815-422-8
• NSC Number: 106256
• DSSTox Substance ID: DTXSID80295912
• Wikidata: Q82036135
• Mol file: 6134-54-9.mol

Synonyms:5-bromo-2,3-dihydro-1H-indene;5-bromoindane;6134-54-9;5-BROMO-INDAN;1H-indene, 5-bromo-2,3-dihydro-;MFCD09842508;5-bromo-indane;NSC106256;SCHEMBL1468326;DTXSID80295912;UMEFRXDFDVRHMJ-UHFFFAOYSA-N;AKOS008119171;MB07871;NSC-106256;SY040210;TS-00313;AM20040860;CS-0137904;FT-0706192;EN300-55657;Y10449;A868735;Z359513410;InChI=1/C9H9Br/c10-9-5-4-7-2-1-3-8(7)6-9/h4-6H,1-3H

Chemical Property of 5-bromo-2,3-dihydro-1H-indene

Chemical Property:

• Vapor Pressure: 0.071mmHg at 25°C
• Melting Point: -7 °C
• Boiling Point: 236.9°C at 760 mmHg
• Flash Point: 99.8°C
• PSA: 0.00000
• Density: 1.462g/cm³
• LogP: 2.93780
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 0
• Exact Mass: 195.98876
• Heavy Atom Count: 10
• Complexity: 122

Purity/Quality:

98% ^*data from raw suppliers

5-Bromoindane 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC2=C(C1)C=C(C=C2)Br

Technology Process of 5-bromo-2,3-dihydro-1H-indene

There total 13 articles about 5-bromo-2,3-dihydro-1H-indene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

triethylsilane (617-86-7) + 5-Bromo-1-indanone (34598-49-7) → 5-bromoindane (6134-54-9)

Guidance literature:

With hydrogen fluoride; In pyridine; at 0 - 20 ℃; for 51h;

Reference yield: 42.0%

indan-5-amine (24425-40-9) → 5-bromoindane (6134-54-9)

Guidance literature:

indan-5-amine; With hydrogen bromide; sodium nitrite; at 0 - 5 ℃; for 0.333333h;

With hydrogen bromide; copper(I) bromide; at 60 ℃; for 0.666667h;

DOI:10.1016/j.bmcl.2005.08.038

Reference yield: 33.0%

INDANE (496-11-7) → 5-bromoindane (6134-54-9)

Guidance literature:

With bromine; aluminum oxide; for 0.1h;

upstream raw materials:

INDANE

5-Bromo-1-indanone

indan-5-amine

bromine

Downstream raw materials:

α-methyl-5-indane methanol

4-bromophthalic acid

5-{[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-4-[4-(2,3-dihydro-1H-inden-5-yl)phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

2-(2,3-dihydro-1H-inden-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Refernces

• 1、 Qin, Haitao,Cai, Wangshui,Wang, Shuang,Guo, Ting,Li, Guigen,Lu, Hongjian. "N-Atom Deletion in Nitrogen Heterocycles". supporting information. p. 20678 - 20683. Retrieved 2021/08/25.
• 2、 -. "FUSED HETEROCYCLIC COMPOUNDS AND THROMBOPOIETIN RECEPTOR ACTIVATORS". Page/Page column 32. . Retrieved 2012/08/28.