2,6-Difluoro-p-phenylenediamine

Base Information

• Chemical Name: 2,6-Difluoro-p-phenylenediamine
• CAS No.: 3743-86-0
• Molecular Formula: C₆H₆F₂N₂
• Molecular Weight: 144.124
• NSC Number: 81295
• UNII: 6CF73PUY2Q
• DSSTox Substance ID: DTXSID40190878
• Nikkaji Number: J50.198K
• Wikidata: Q83063339
• Mol file: 3743-86-0.mol

Synonyms:2,6-Difluoro-p-phenylenediamine;3743-86-0;2,6-difluorobenzene-1,4-diamine;p-Phenylenediamine, 2,6-difluoro-;1,4-Diamino-2,6-difluorobenzene;6CF73PUY2Q;NSC-81295;NSC 81295;BRN 2718137;2,6-difluoro-1,4-phenylenediamine;NSC81295;UNII-6CF73PUY2Q;WLN: ZR DZ BF FF;p-Phenylenediamine,6-difluoro-;SCHEMBL5080236;DTXSID40190878;2,6-Difluoro-1,4-benzenediamine;MFCD01706704;1,4-Benzenediamine, 2,6-difluoro-;AKOS009158249

Chemical Property of 2,6-Difluoro-p-phenylenediamine

Chemical Property:

• Vapor Pressure: 0.0465mmHg at 25°C
• Boiling Point: 236.8°Cat760mmHg
• Flash Point: 102.9°C
• Density: 1.407g/cm³
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 144.04990452
• Heavy Atom Count: 10
• Complexity: 108

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=C(C(=C1F)N)F)N

Technology Process of 2,6-Difluoro-p-phenylenediamine

There total 5 articles about 2,6-Difluoro-p-phenylenediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-Difluor-4'-nitro-4-amino-azobenzol (3743-89-3) → 2,6-difluoro-1,4-phenylenediamine (3743-86-0)

Guidance literature:

Multi-step reaction with 3 steps

1: AcOH / Heating

2: aq. N₂H₄ / Pd-C / ethanol / Heating

3: aq. HCl / Heating

With hydrogenchloride; hydrazine hydrate; acetic acid; palladium on activated charcoal; In ethanol;

DOI:10.1021/jo01022a067

Reference yield:

2,6-Difluor-4'-nitro-4-acetamido-azobenzol (3743-87-1) → 2,6-difluoro-1,4-phenylenediamine (3743-86-0)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. N₂H₄ / Pd-C / ethanol / Heating

2: aq. HCl / Heating

With hydrogenchloride; hydrazine hydrate; palladium on activated charcoal; In ethanol;

DOI:10.1021/jo01022a067

Reference yield:

Sodium; (3,5-difluoro-phenylamino)-methanesulfonate → 2,6-difluoro-1,4-phenylenediamine (3743-86-0)

Guidance literature:

Multi-step reaction with 4 steps

1: (i) NaNO₂, aq. HCl, (ii) /BRN= 7011785/

2: AcOH / Heating

3: aq. N₂H₄ / Pd-C / ethanol / Heating

4: aq. HCl / Heating

With hydrogenchloride; hydrazine hydrate; acetic acid; palladium on activated charcoal; In ethanol;

DOI:10.1021/jo01022a067

upstream raw materials:

3,5-Difluor-4-amino-acetanilid

1,3-dichloro-2,4,6-trifluorobenzene

2,6-Difluor-4'-nitro-4-amino-azobenzol

2,6-Difluor-4'-nitro-4-acetamido-azobenzol

Downstream raw materials:

3,5-Difluor-azobenzol

3,5-Difluor-4-(N-methyl-formamido)-azobenzol

3,5-Difluor-4-acetamido-azobenzol

3,5-Difluor-4-formamido-azobenzol

Refernces