2-Anilinopyridine

Base Information

• Chemical Name: 2-Anilinopyridine
• CAS No.: 6631-37-4
• Molecular Formula: C11H10N2
• Molecular Weight: 170.214
• Hs Code.: 2933399090
• European Community (EC) Number: 229-625-9
• NSC Number: 53090
• DSSTox Substance ID: DTXSID40216522
• Nikkaji Number: J81.252H
• Wikidata: Q72498516
• ChEMBL ID: CHEMBL555260
• Mol file: 6631-37-4.mol

Synonyms:2-Anilinopyridine;n-phenylpyridin-2-amine;6631-37-4;N-2-Pyridylaniline;2-PHENYLAMINOPYRIDINE;N-Phenyl-N-(2-pyridinyl)amine;N-phenyl-2-pyridinamine;CHEMBL555260;EINECS 229-625-9;MFCD00006248;phenyl-2-pyridylamine;Anilino-Pyridine;phenylaminopyridine;NSC53090;2-pyridylideneaniline;N-(2-Pyridyl)aniline;Enamine_005461;N-phenylpyridine-2-amine;2-(N-phenylamino)pyridine;2-Pyridinamine, N-phenyl-;Oprea1_397072;MLS000536171;BIDD:GT0178;SCHEMBL626575;DTXSID40216522;HMS1409I05;HMS2353G12;N-Phenyl-N-(2-pyridinyl)amine #;AMY20169;STR05335;BDBM50295564;NSC 53090;NSC-53090;STK945098;AKOS001044180;AC-3365;SB52449;NCGC00246063-01;SMR000155519;SY004358;CS-0095245;FT-0636212;EN300-16204;A24654;J-523759;Z54630900

Chemical Property of 2-Anilinopyridine

Chemical Property:

• Vapor Pressure: 0.000966mmHg at 25°C
• Melting Point: 106-112℃
• Refractive Index: 1.642
• Boiling Point: 302.8 °C at 760 mmHg
• PKA: 5.58±0.10(Predicted)
• Flash Point: 136.9 °C
• PSA: 24.92000
• Density: 1.144 g/cm³
• LogP: 2.89820
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 170.084398327
• Heavy Atom Count: 13
• Complexity: 141

Purity/Quality:

99% ^*data from raw suppliers

2-Anilinopyridine ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)NC2=CC=CC=N2

Technology Process of 2-Anilinopyridine

There total 69 articles about 2-Anilinopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-bromo-pyridine (109-04-6) + aniline (62-53-3) → 2-(phenylamino)pyridine (6631-37-4)

Guidance literature:

With (1,3-bis(2,6-diisopropylphenyl)-3,4,5,6-tetrahydropyrimidin-2-ylidene)Pd(cinnamyl, 3-phenylallyl)Cl; sodium t-butanolate; In neat (no solvent); at 110 ℃; for 12h; Inert atmosphere; Green chemistry;

DOI:10.1002/ejoc.201501616

Reference yield: 99.0%

2-chloropyridine (109-09-1) + aniline (62-53-3) → 2-(phenylamino)pyridine (6631-37-4)

Guidance literature:

With (1,3-bis(2,6-diisopropylphenyl)-3,4,5,6-tetrahydropyrimidin-2-ylidene)Pd(cinnamyl, 3-phenylallyl)Cl; sodium t-butanolate; In neat (no solvent); at 110 ℃; for 12h; Inert atmosphere; Green chemistry;

DOI:10.1002/ejoc.201501616

Reference yield: 96.0%

2-aminopyridine (504-29-0) + 1,1'-sulfinylbisbenzene (945-51-7) → 2-(phenylamino)pyridine (6631-37-4)

Guidance literature:

With SingaCycle-A₁; potassium hexamethylsilazane; In toluene; at 100 ℃; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1055/s-0037-1611732

upstream raw materials:

2-aminopyridine

bromobenzene

iodobenzene

2-chloropyridine

Downstream raw materials:

nitroso-phenyl-[2]pyridyl-amine

1-azaphenothiazine

2C₁₁H₉N₂^(1-)*3C₆H₁₈N₃OP*2Na⁽¹⁺⁾

C₁₇H₁₆N₂O₂

Refernces

• 1、 Chattopadhyay, Buddhadeb,Hassan, Mirja Md Mahamudul,Hoque, Md Emdadul. "Remarkably Efficient Iridium Catalysts for Directed C(sp2)-H and C(sp3)-H Borylation of Diverse Classes of Substrates". supporting information. p. 5022 - 5037. Retrieved 2021/05/04.
• 2、 Di, Jia-Qi,Zhang, Mo,Chen, Yu-Xuan,Wang, Jin-Xin,Geng, Shan-Shan,Tang, Jia-Qi,Zhang, Zhan-Hui. "Copper anchored on phosphorus g-C3N4as a highly efficient photocatalyst for the synthesis ofN-arylpyridin-2-amines". . p. 1041 - 1049. Retrieved 2021/02/09.