AC-PHE-LYS-OH

Base Information

• Chemical Name: AC-PHE-LYS-OH
• CAS No.: 14287-21-9
• Molecular Formula: C17H25N3O4
• Molecular Weight: 335.4
• Mol file: 14287-21-9.mol

Synonyms:N-Acetyl-phe-lys;

Chemical Property of AC-PHE-LYS-OH

Chemical Property:

• Vapor Pressure: 1.72E-19mmHg at 25°C
• Refractive Index: 1.55
• Boiling Point: 681.2 °C at 760 mmHg
• PKA: 3.31±0.10(Predicted)
• Flash Point: 365.8 °C
• PSA: 121.52000
• Density: 1.19 g/cm³
• LogP: 1.91430
• Storage Temp.: -15°C

Purity/Quality:

99% ^*data from raw suppliers

Ac-Phe-Lys-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ac-Phe-Lys-OH can be used as targeted mTOR inhibitors.

Technology Process of AC-PHE-LYS-OH

There total 3 articles about AC-PHE-LYS-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

(S)-2-acetylamino-3-phenylpropanoic acid (2018-61-3) + L-Lysine hydrochloride (657-27-2,10098-89-2,26124-78-7) → Ac-Phe-Lys-OH (14287-21-9)

Guidance literature:

With Z⁽²⁰⁾-chymotrypsin; In phosphate buffer; ethyl acetate; at 37 ℃; for 24h; pH=6.7;

DOI:10.1271/bbb.63.1156

Reference yield: 10.0%

L-lysine (56-87-1,3506-25-0) + (S)-2-acetylamino-3-phenylpropanoic acid (2018-61-3) → Ac-Phe-Lys-OH (14287-21-9)

Guidance literature:

In dichloromethane; water; at 37 ℃; for 24h; Z⁽²⁰⁾Csin (Chymotrypsin, modified with a benzyloxycarbonyl group), 0.15 M phosphate buffer (pH = 6.7); other solvents; other amino acids, other N-acyl amino acids or peptide derivatives;

DOI:10.1271/bbb.56.441

Reference yield:

C36H37ClN3O4Pol → Ac-Phe-Lys-OH (14287-21-9)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 0.0333333h; copoly(styrene-divinylbenzene)

upstream raw materials:

L-lysine

(S)-2-acetylamino-3-phenylpropanoic acid

L-Lysine hydrochloride

Refernces

• 1、 Oaki, Jiro,Nakahara, Kayoko,Tamura, Masahiro,Okai, Hideo. "One step synthesis of inverted aspartame type sweetener, Ac-Phe-Lys, using chemically modified chymotrypsin". . p. 1156 - 1159. Retrieved 2007/10/03.