16-bromoestrone

Base Information

• Chemical Name: 16-bromoestrone
• CAS No.: 71765-95-2
• Molecular Formula: C₁₈H₂₁BrO₂
• Molecular Weight: 349.268
• Mol file: 71765-95-2.mol

Synonyms:Estra-1,3,5(10-trien-17-one,16a-bromo-3-hydroxy- (7CI); 16a-Bromoestrone

Chemical Property of 16-bromoestrone

Chemical Property:

• Vapor Pressure: 6.93E-10mmHg at 25°C
• Boiling Point: 481.2°C at 760 mmHg
• Flash Point: 244.8°C
• PSA: 37.30000
• Density: 1.416g/cm³
• LogP: 4.19080

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 16-bromoestrone

There total 9 articles about 16-bromoestrone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Estrone (53-16-7) → 16alpha-Bromoestrone (71765-95-2)

Guidance literature:

With copper(ll) bromide; In methanol; Heating;

DOI:10.1016/0039-128X(81)90054-4

Reference yield: 86.0%

16α-bromo-3-hydroxy-1,3,5(10)-estratrien-17-one 3-acetate (1239-35-6) → 16alpha-Bromoestrone (71765-95-2)

Guidance literature:

With sulfuric acid; In ethanol; Ambient temperature;

DOI:10.1021/jm00183a007

Reference yield: 75.0%

16α-bromo-3-hydroxy-1,3,5(10)-estratrien-17-one 3-acetate (1239-35-6) → 16alpha-Bromoestrone (71765-95-2) + 16beta-Bromoestrone (1228-71-3)

Guidance literature:

With sulfuric acid; for 140h; Heating;

DOI:10.1021/jo00330a005

upstream raw materials:

16α-bromo-3-hydroxy-1,3,5(10)-estratrien-17-one 3-acetate

Estrone

estra-1,3,5⁽¹⁰⁾,16-tetraene-3,17-diol diacetate

oestrone acetate

Downstream raw materials:

sodium 17-oxo-16α-hydroxy-1,3,5(10)-estratrien-3-yl sulfate

sodium 16-oxo-17β-hydroxy-1,3,5(10)-estratrien-3-yl sulfate

17β-cyano-16α,17α-epoxy-1,3,5(10)-estratrien-3-ol

Refernces

• 1、 Fedorova, O. I.,Morozova, L. S.,Alekseeva, L. M.,Grinenko, G. S.. "PREPARATION OF 16-SUBSTITUTED 3-HYDROXYESTRA-1,3,5(10)-TRIENE-17-ONE STARTING WITH THE BROMINATION OF ESTRONE ACETATE". . p. 437 - 440. Retrieved 2007/10/02.
• 2、 Arunachalam, Thangavel,Caspi, Eliahu. "Syntheses of Seleno Estrogens". . p. 3415 - 3420. Retrieved 2007/10/02.