2-(4-CHLORO-2-METHYLPHENOXY)ACETIC ACID HYDRAZIDE

Base Information

• Chemical Name: 2-(4-CHLORO-2-METHYLPHENOXY)ACETIC ACID HYDRAZIDE
• CAS No.: 32022-38-1
• Molecular Formula: C9H11ClN2O2
• Molecular Weight: 214.652
• Hs Code.: 2928009090
• Mol file: 32022-38-1.mol

Synonyms:Aceticacid, (4-chloro-2-methylphenoxy)-, hydrazide (9CI);Acetic acid,[(4-chloro-o-tolyl)oxy]-, hydrazide (7CI,8CI);4-Chloro-2-methylphenoxyaceticacid hydrazide;MCPA hydrazide;

Chemical Property of 2-(4-CHLORO-2-METHYLPHENOXY)ACETIC ACID HYDRAZIDE

Chemical Property:

• Vapor Pressure: 1.63E-07mmHg at 25°C
• Melting Point: 149-151 °C
• Refractive Index: 1.562
• Boiling Point: 427.5 °C at 760 mmHg
• PKA: 12.11±0.35(Predicted)
• Flash Point: 212.4 °C
• PSA: 64.35000
• Density: 1.279 g/cm³
• LogP: 2.10830
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

2-(4-chloro-2-methylphenoxy)acetohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-CHLORO-2-METHYLPHENOXY)ACETIC ACID HYDRAZIDE

There total 4 articles about 2-(4-CHLORO-2-METHYLPHENOXY)ACETIC ACID HYDRAZIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

ethyl 2-(4-chloro-2-methylphenoxy)acetate (2698-38-6) → 2-(4-chloro-2-methylphenoxy)acetic acid hydrazide (32022-38-1)

Guidance literature:

With hydrazine hydrate; In ethanol; at 20 ℃;

DOI:10.1016/j.molstruc.2021.132173

Reference yield:

methyl 2-(4-chloro-2-methylphenoxy)acetate (2436-73-9) → 2-(4-chloro-2-methylphenoxy)acetic acid hydrazide (32022-38-1)

Guidance literature:

With hydrazine hydrate; In ethanol; for 6h; Reflux;

DOI:10.3390/molecules22010064

Reference yield:

2-methyl-4-chlorophenol (1570-64-5) → 2-(4-chloro-2-methylphenoxy)acetic acid hydrazide (32022-38-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 90 °C

2: hydrazine hydrate / ethanol / 6 h / Reflux

With hydrazine hydrate; potassium carbonate; In ethanol; N,N-dimethyl-formamide;

DOI:10.3390/molecules22010064

upstream raw materials:

ethyl 2-(4-chloro-2-methylphenoxy)acetate

2-methyl-4-chlorophenol

methyl 2-(4-chloro-2-methylphenoxy)acetate

MCPA

Downstream raw materials:

4-allyl-1-(4-chloro-2-methylphenoxyacetyl)thiosemicarbazide

2-(4-chloro-2-methylphenoxy)-N'-[-(2-chlorophenyl)methylidene]acetohydrazide

2-(4-chloro-2-methylphenoxy)-N'-[(3,4-dichlorophenyl)methylidene]acetohydrazide

2-(4-chloro-2-methylphenoxy)-N'-[(2,6-dichlorophenyl)methylidene]acetohydrazide

Refernces

• 1、 Chai, Jianqi,Chen, Min,Jin, Fei,Kong, Xiangyi,Wang, Xiaobin,Xue, Wei,Yang, Chunlong. "Expedient discovery for novel antifungal leads: 1,3,4-Oxadiazole derivatives bearing a quinazolin-4(3H)-one fragment". . . Retrieved 2021/08/03.
• 2、 Basyouni, Wahid M.,Abbas, Samir Y.,El Shehry, Mohamed F.,El-Bayouki, Khairy A.M.,Aly, Hanan F.,Arafa, Azza,Soliman, Mahmoud S.. "New Biguanides as Anti-Diabetic Agents, Part II: Synthesis and Anti-Diabetic Properties Evaluation of 1-Arylamidebiguanide Derivatives as Agents of Insulin Resistant Type II Diabetes". . . Retrieved 2017/10/23.