2-(Piperazin-1-yl)pyrazine

Base Information

• Chemical Name: 2-(Piperazin-1-yl)pyrazine
• CAS No.: 34803-68-4
• Molecular Formula: C8H12N4
• Molecular Weight: 164.21
• Hs Code.: 29339900
• European Community (EC) Number: 252-221-9
• DSSTox Substance ID: DTXSID50188342
• Nikkaji Number: J289.839J
• Wikidata: Q83060148
• ChEMBL ID: CHEMBL3301989
• Mol file: 34803-68-4.mol

Synonyms:2-(piperazin-1-yl)pyrazine;34803-68-4;1-(2-Pyrazinyl)-piperazine;2-piperazin-1-ylpyrazine;1-(2-pyrazinyl)piperazine;1-Piperazinylpyrazine;1-(pyrazin-2-yl)piperazine;MFCD00040766;EINECS 252-221-9;4-(2-Pyrazinyl)piperazine;N-(Pyrazin-2-yl)piperazine;2-Piperazinopyrazine;1-piperazinyl pyrazine;3,4,5,6-tetrahydro-2h-[1,2']bipyrazinyl;2-(1-piperazinyl)pyrazine;SCHEMBL8040;1-(2-pyrazinyl) piperazine;1-(pyrazin-2-yl)-piperazine;CHEMBL3301989;DTXSID50188342;HCGFLVDMFDHYJD-UHFFFAOYSA-N;BBL027950;STL373214;AKOS000123683;FS-1240;2,3,5,6-tetrahydro[1,2']bipyrazine;1-(2-pyrazinyl)-piperazine, AldrichCPR;SY012688;FT-0694414;EN300-31751;A822407;F2158-0968;2-piperazin-4-ium-1-ylpyrazine;(Pyrazin-2-yl)-piperazine

Chemical Property of 2-(Piperazin-1-yl)pyrazine

Chemical Property:

• Appearance/Colour: yellow crystalline powder or chunks
• Vapor Pressure: 0.000245mmHg at 25°C
• Boiling Point: 324.482 °C at 760 mmHg
• PKA: 8.63±0.10(Predicted)
• Flash Point: 150.042 °C
• PSA: 41.05000
• Density: 1.139 g/cm³
• LogP: 0.28000
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 164.106196400
• Heavy Atom Count: 12
• Complexity: 133

Purity/Quality:

99% ^*data from raw suppliers

2-(piperazin-1-yl)pyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 37/39-26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1)C2=NC=CN=C2

Technology Process of 2-(Piperazin-1-yl)pyrazine

There total 3 articles about 2-(Piperazin-1-yl)pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

piperazine (110-85-0) + 2-chloropyrazin (14508-49-7) → 1-(pyrazin-2-yl)piperazine (34803-68-4)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl; sodium t-butanolate; In 1,4-dioxane; at 100 ℃; for 0.166667h; Temperature;

DOI:10.1021/acs.orglett.6b02591

Reference yield:

tert-butyl 4-(pyrazin-2-yl)piperazine-1-carboxylate (622386-07-6) → 1-(pyrazin-2-yl)piperazine (34803-68-4)

Guidance literature:

tert-butyl 4-(pyrazin-2-yl)piperazine-1-carboxylate; With macroporous polymer-supported-SO₃H; In dichloromethane; at 20 ℃;

With ammonium hydroxide; In methanol;

DOI:10.1016/j.tetlet.2006.02.047

Reference yield:

→ 1-(pyrazin-2-yl)piperazine (34803-68-4)

Guidance literature:

DOI:10.1021/jm00204a007

upstream raw materials:

piperazine

2-chloropyrazin

tert-butyl 4-(pyrazin-2-yl)piperazine-1-carboxylate

Downstream raw materials:

2-bromo-5-(piperazin-1-yl)pyrazine

Ethyl 3-phenyl-3-(5-{[4-(2-pyrazinyl)-1-piperazinyl]carbonyl}-1H-benzimidazol-1-yl)propanoate

Refernces

• 1、 Duncton, Matthew A. J.,Roffey, Jonathan R. A.,Hamlyn, Richard J.,Adams, David R.. "Parallel synthesis of N-arylpiperazines using polymer-assisted reactions". . p. 2549 - 2552. Retrieved 2007/10/03.
• 2、 -. "Phenylsulfonyl-1,3-dihydro-2h-indole-2-one derivatives, their preparation and their therapeutic use". Page/Page column 38. . Retrieved 2010/02/08.