Ethanone, 2-(dimethylamino)-1-phenyl-

Base Information Edit

Chemical Name:Ethanone, 2-(dimethylamino)-1-phenyl-
CAS No.:3319-03-7
Molecular Formula:C10H13NO
Molecular Weight:163.219
Hs Code.:2922399090
NSC Number:129395
DSSTox Substance ID:DTXSID70186840
Nikkaji Number:J101.479J
Wikidata:Q83058245
Mol file:3319-03-7.mol

Synonyms:3319-03-7;Ethanone, 2-(dimethylamino)-1-phenyl-;2-(Dimethylamino)-1-phenylethanone;2-(Dimethylamino)acetophenone;2-(DIMETHYLAMINO)-1-PHENYLETHAN-1-ONE;alpha-(Dimethylamino)acetophenone;Acetophenone, 2-(dimethylamino)-;[(Dimethylamino)acetyl]benzene;2-(N,N-Dimethylamino)acetophenone;.alpha.-(Dimethylamino)acetophenone;2-dimethylaminoacetophenone;NCIOpen2_001857;SCHEMBL182321;DTXSID70186840;2-(N,N-dimethylamino) acetophenone;NSC129395;2-(Dimethylamino)-1-phenylethanone #;AKOS008964704;NSC 129395;NSC-129395;EN300-244228

Suppliers and Price of Ethanone, 2-(dimethylamino)-1-phenyl-

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 7 raw suppliers

Chemical Property of Ethanone, 2-(dimethylamino)-1-phenyl- Edit

Chemical Property:

Vapor Pressure:0.0298mmHg at 25°C
Boiling Point:244.8°Cat760mmHg
Flash Point:83.6°C
PSA：20.31000
Density:1.012g/cm³
LogP:1.43090
Solubility.:DCM, Ethyl Amine
XLogP3:1.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:163.099714038
Heavy Atom Count:12
Complexity:148

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(C)CC(=O)C1=CC=CC=C1
Uses 2-(Dimethylamino)acetophenone is an intermediate in the synthesis of 1-(Dimethylamino)-2-phenyl-2-butanyl 3,4,5-trimethoxybenzoate (D493076) which is a degradation product of trimebutine maleate and an impurity of trimebutine. Trimebutine is an opioid receptor agonist and an antispasmodic agent (1,2). It is used to treat acute and chronic abdominal pain.

Technology Process of Ethanone, 2-(dimethylamino)-1-phenyl-

There total 14 articles about Ethanone, 2-(dimethylamino)-1-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 124-40-3
dimethyl amine

: 70-11-1
α-bromoacetophenone

: 3319-03-7
2-dimethylamino-1-phenyl-ethanone

Guidance literature:: With potassium carbonate; In acetonitrile; at 20 ℃; Inert atmosphere;
DOI:10.1021/ja204717b

Reference yield: 44.0%

: 926-64-7
N,N-Dimethylamino acetonitrile

: 71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1
benzene

: 3319-03-7
2-dimethylamino-1-phenyl-ethanone

Guidance literature:: N,N-Dimethylamino acetonitrile; benzene; With trifluorormethanesulfonic acid; In dichloromethane; at 60 - 80 ℃; Inert atmosphere;

With water; In dichloromethane; Inert atmosphere; Cooling with ice;

With sodium hydroxide; In water; Inert atmosphere;
DOI:10.1016/j.tet.2011.04.038

Reference yield:

: 73620-29-8
dimethylallylphenacylammonium bromide

: 3319-03-7
2-dimethylamino-1-phenyl-ethanone

: 73620-31-2
phenyl 1-dimethylamino-3-butenyl ketone

: 98-86-2
acetophenone

Guidance literature:: With sodium; In dimethyl sulfoxide; at 30 - 35 ℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts; further solvents, temperatures and base;