ROBINETIN

Base Information

• Chemical Name: ROBINETIN
• CAS No.: 490-31-3
• Molecular Formula: C15H10 O7
• Molecular Weight: 302.24
• Hs Code.: 2932999099
• Mol file: 490-31-3.mol

Synonyms:Flavone,3,3',4',5',7-pentahydroxy- (8CI); Robinetin (6CI);3,3',4',5',7-Pentahydroxyflavone; 3,7,3',4',5'-Pentahydroxyflavone; NSC 407331;NSC 656274; Norkanugin

Chemical Property of ROBINETIN

Chemical Property:

• Vapor Pressure: 7.35E-19mmHg at 25°C
• Melting Point: 326-328°C
• Refractive Index: 1.4790 (estimate)
• Boiling Point: 669.9 °C at 760 mmHg
• PKA: 6.82±0.40(Predicted)
• Flash Point: 258.6 °C
• PSA: 131.36000
• Density: 1.799 g/cm³
• LogP: 1.98800
• Storage Temp.: 2-8°C
• Solubility.: DMSO (Sparingly), Methanol (Slightly, Heated)

Purity/Quality:

98%,99%, ^*data from raw suppliers

Robinetin ^*data from reagent suppliers

Safty Information:

• Statements: 22
• Safety Statements: 22-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ROBINETIN

There total 15 articles about ROBINETIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

7-benzyloxy-3-hydroxy-2-(3,4,5-trimethoxy-phenyl)-chromen-4-one (354119-95-2) → robinetin (490-31-3)

Guidance literature:

With boron tribromide; In dichloromethane; at 20 ℃; for 22h;

DOI:10.1016/j.bmc.2004.02.031

Reference yield: 81.0%

3-Hydroxy-7,3',4',5'-tetramethoxyflavone → robinetin (490-31-3)

Guidance literature:

With boron tribromide; In dichloromethane; at 20 ℃; for 48h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.6b00698

Reference yield:

1-[4-(benzyloxy)-2-hydroxyphenyl]ethanone (29682-12-0) → robinetin (490-31-3)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydroxide / ethanol / 144 h

2: 84 mg / H₂O₂; NaOH / tetrahydrofuran; H₂O / 47 h / cooling

3: 99 percent / boron tribromide / CH₂Cl₂ / 22 h / 20 °C

With potassium hydroxide; sodium hydroxide; dihydrogen peroxide; boron tribromide; In tetrahydrofuran; ethanol; dichloromethane; water; 1: aldol condensation / 2: Algar-Flynn-Oyamada oxidation;

DOI:10.1016/j.bmc.2004.02.031

upstream raw materials:

Robinetin trimethyl ether

3,7,3'-trimethoxy-4',5'-dihydroxyflavone

7-hydroxy-3-methoxy-2-(3,4,5-trimethoxy-phenyl)-chromen-4-one

Dihydrorobinetin

Downstream raw materials:

3,7-diacetoxy-2-(3,4,5-triacetoxy-phenyl)-chromen-4-one

3,7,3',4',5'-O-pentamethylrobinetin

Refernces

• 1、 Bennett, Christopher J.,Caldwell, Stuart T.,McPhail, Donald B.,Morrice, Philip C.,Duthie, Garry G.,Hartley, Richard C.. "Potential therapeutic antioxidants that combine the radical scavenging ability of myricetin and the lipophilic chain of vitamin E to effectively inhibit microsomal lipid peroxidation". . p. 2079 - 2098. Retrieved 2007/10/03.