Indriline

Base Information

• Chemical Name: Indriline
• CAS No.: 7395-90-6
• Molecular Formula: C19H21 N
• Molecular Weight: 263.38
• Hs Code.: 2921499090
• UNII: J2LLI1K6QQ
• DSSTox Substance ID: DTXSID90864052
• Nikkaji Number: J8.928A
• Wikidata: Q27281069
• NCI Thesaurus Code: C170068
• ChEMBL ID: CHEMBL2110854
• Mol file: 7395-90-6.mol

Synonyms:INDRILINE;7395-90-6;Indriline [INN];N,N-dimethyl-2-(1-phenylinden-1-yl)ethanamine;UNII-J2LLI1K6QQ;J2LLI1K6QQ;Indrilene hydrochloride;1H-Indene-1-ethanamine, N,N-dimethyl-1-phenyl-;NSC169093;LU 3-083;SCHEMBL124200;CHEMBL2110854;DTXSID90864052;Indene-1-ethylamine, N,N-dimethyl-1-phenyl-;N,N-Dimethyl-1-phenyl-1H-indene-1-ethanamine;N,N-DIMETHYL-1-PHENYLINDENE-1-ETHYLAMINE;N,N-Dimethyl-2-(1-phenyl-1H-inden-1-yl)ethanamine;N,N-Dimethyl-2-(1-phenyl-1H-inden-1-yl)ethanamine-;Q27281069;1H-Indene-1-ethanamine, N,N-dimethyl-1-phenyl- (9CI);N, N-Dimethyl-1-phenylindene-1-ethylamine hydrochloride;{1-[(2-Dimethylamino)ethyl]-1-phenylindene} hydrochloride;N,N-Dimethyl-N-(2-(1-phenyl-1H-inden-1-yl)ethyl)amine;(+/-)-1H-INDENE-1-ETHANAMINE, N,N-DIMETHYL-1-PHENYL-

Chemical Property of Indriline

Chemical Property:

• Vapor Pressure: 1.32E-05mmHg at 25°C
• Boiling Point: 367.9°C at 760 mmHg
• PKA: 9.50±0.28(Predicted)
• Flash Point: 158.8°C
• PSA: 3.24000
• Density: 1.044g/cm³
• LogP: 3.95120
• XLogP3: 4.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 263.167399674
• Heavy Atom Count: 20
• Complexity: 340

Purity/Quality:

99%, ^*data from raw suppliers

INDRILINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CCC1(C=CC2=CC=CC=C21)C3=CC=CC=C3
• Uses: Stimulant (central).

Technology Process of Indriline

There total 3 articles about Indriline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-phenyl-1H-indene (1961-97-3) + 2-(dimethylamino)ethyl chloride (107-99-3) → nortryptiline (7395-90-6)

Guidance literature:

Multistep reaction; (i) nBuLi, hexane, Et₂O, (ii) /BRN= 605280/, Et₂O;

DOI:10.1021/jm00315a029

Reference yield:

3-phenyl-2,3-dihydro-1H-inden-1-ol (30516-40-6) + 2-(dimethylamino)ethyl chloride (107-99-3) → nortryptiline (7395-90-6)

Guidance literature:

Multistep reaction; (i) Na, liq. NH₃, Et₂O, (ii) /BRN= 605280/, Et₂O, xylene, (iii) aq. HCl;

DOI:10.1021/jm00315a029

Reference yield:

→ nortryptiline (7395-90-6)

Guidance literature:

d. 3-Phenyl-inden-Na-Verb, 2-Dimethylamino-ethylchlorid in Toluol + DMF, 60-80grad, neben anderen Verbb.;

upstream raw materials:

3-phenyl-1H-indene

2-(dimethylamino)ethyl chloride

3-phenyl-2,3-dihydro-1H-inden-1-ol

Downstream raw materials:

1-(2-Dimethylaminoethyl)-1-phenylindene N-Oxide

1-(2-Methylaminoethyl)-1-phenylindene

1-(2-Dimethylaminoethyl)-1-phenyl-indan