S-(5'-Deoxy-5'-adenosyl)methionine iodide

Base Information

• Chemical Name: S-(5'-Deoxy-5'-adenosyl)methionine iodide
• CAS No.: 3493-13-8
• Molecular Formula: C15H23 N6 O5 S . I
• Molecular Weight: 526.355
• European Community (EC) Number: 222-486-5
• Mol file: 3493-13-8.mol

Synonyms:EINECS 222-486-5;AKOS024284735;S-(5'-Deoxy-5'-adenosyl)methionine iodide;FT-0773528

Chemical Property of S-(5'-Deoxy-5'-adenosyl)methionine iodide

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 207.93000
• Density: g/cm³
• LogP: -3.63670
• Storage Temp.: −20°C
• Solubility.: H2O: 100 mg/mL
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 7
• Exact Mass: 526.04954
• Heavy Atom Count: 28
• Complexity: 533

Purity/Quality:

98%,99%, ^*data from raw suppliers

S-(5′-Adenosyl)-L-methionine iodide ≥80% (HPLC), ≥80% (spectrophotometric assay) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-24/25-36-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C[S+](CCC(C(=O)O)N)CC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)O.[I-]
• Uses: S-(5′-Adenosyl)-L-methionine (SAM, AdoMet) is used as a primary methyl donor molecule in mammalian cell culture and the first step metabolite in methionine biosynthesis.

Technology Process of S-(5'-Deoxy-5'-adenosyl)methionine iodide

There total 4 articles about S-(5'-Deoxy-5'-adenosyl)methionine iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

methyl iodide (74-88-4) + S-(5'-adenosyl)-L-homocysteine (979-92-0) → S-(5′-adenosyl)-L-methionine iodide (3493-13-8)

Guidance literature:

With silver perchlorate; acetic acid; In formic acid; at 22 ℃; for 8h;

DOI:10.1021/ol501169y

Reference yield:

→ S-(5′-adenosyl)-L-methionine iodide (3493-13-8)

Guidance literature:

DOI:10.1021/jm00231a005 DOI:10.1021/jm00231a004

Reference yield:

methyl iodide (74-88-4) + (S)-5’-(S)-(3-amino-3-carboxypropyl)-5’-thioadenosine (53276-26-9) → S-adenosyl-L-methionine iodide (3493-13-8,79297-25-9,79297-26-0)

Guidance literature:

In formic acid; for 96h; Ambient temperature;

DOI:10.1016/S0031-9422(00)81092-4

upstream raw materials:

methyl iodide

(S)-5’-(S)-(3-amino-3-carboxypropyl)-5’-thioadenosine

S-(5'-adenosyl)-L-homocysteine

Downstream raw materials:

C₂₂H₂₃O₁₂⁽¹⁺⁾

peonidin 3-O-glucoside

2-(5-hydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-3-methoxy-5-methylbenzaldehyde

Refernces

• 1、 Borchardt et al.. "". . p. 1104,1105. Retrieved 1976.
• 2、 Creason, Gary L.,Madison, James T.,Thompson, John F.. "SOYBEANS AND RADISH LEAVES CONTAIN ONLY ONE OF THE SULFONIUM DIASTEREOISOMERS OF S-ADENOSYLMETHIONINE". . p. 1151 - 1156. Retrieved 2007/10/02.