Technology Process of 3,6a,9-Trimethyl-7-(propan-2-yl)hexahydro-6,9-methanobenzo[1,2]pentaleno[1,6-bc]furan-4,6,7,8a,8b,9a(6aH,9H)-hexol
There total 5 articles about 3,6a,9-Trimethyl-7-(propan-2-yl)hexahydro-6,9-methanobenzo[1,2]pentaleno[1,6-bc]furan-4,6,7,8a,8b,9a(6aH,9H)-hexol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
lithium;
In
tetrahydrofuran; ammonia;
at -78 ℃;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 71 percent / CF3CO3H, NaHCO3 / 1,2-dichloro-ethane; acetonitrile / 20 h / Ambient temperature
2: 75 percent / Li / liquid ammonia; tetrahydrofuran / 0.5 h / -78 °C
With
trifluoroacetyl peroxide; lithium; sodium hydrogencarbonate;
In
tetrahydrofuran; ammonia; 1,2-dichloro-ethane; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) LDA; 2.) Li / 1.) THF, -78 deg C, 30 min; 2.) THF, NH3 (liq.), -78 deg C, 1 h
2: 89 percent / H2SO4 / methanol / 40 h / Heating
3: 71 percent / CF3CO3H, NaHCO3 / 1,2-dichloro-ethane; acetonitrile / 20 h / Ambient temperature
4: 75 percent / Li / liquid ammonia; tetrahydrofuran / 0.5 h / -78 °C
With
trifluoroacetyl peroxide; sulfuric acid; lithium; sodium hydrogencarbonate; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; ammonia; 1,2-dichloro-ethane; acetonitrile;