(4-Chlorophenyl)(morpholino)methanone

Base Information

• Chemical Name: (4-Chlorophenyl)(morpholino)methanone
• CAS No.: 19202-04-1
• Molecular Formula: C11H12 Cl N O2
• Molecular Weight: 225.675
• Hs Code.: 2934999090
• Mol file: 19202-04-1.mol

Synonyms:Morpholine,4-(4-chlorobenzoyl)- (9CI); Morpholine, 4-(p-chlorobenzoyl)- (8CI);4-(p-Chlorobenzoyl)morpholine; 4-Chlorobenzmorpholide;N-(4-Chlorobenzoyl)morpholine; NSC 14842

Chemical Property of (4-Chlorophenyl)(morpholino)methanone

Chemical Property:

• Vapor Pressure: 4.75E-06mmHg at 25°C
• Melting Point: 76 °C
• Boiling Point: 382.4°Cat760mmHg
• PKA: -1.73±0.20(Predicted)
• Flash Point: 185°C
• PSA: 29.54000
• Density: 1.271g/cm³
• LogP: 1.75030
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

(4-Chlorophenyl)(morpholino)methanone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-Chlorophenyl)(morpholino)methanone

There total 42 articles about (4-Chlorophenyl)(morpholino)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

morpholine (110-91-8,99108-56-2) + 1-Chloro-4-iodobenzene (637-87-6) + carbon monoxide (201230-82-2) → N-(4-chlorobenzoyl)morpholine (19202-04-1)

Guidance literature:

With dipotassium hydrogenphosphate; palladium; potassium iodide; In 1,4-dioxane; at 130 ℃; for 12h; under 3750.38 Torr; Autoclave; Green chemistry;

DOI:10.1039/c8gc00740c

Reference yield: 99.0%

4-[1-(4-chloro-phenyl)-vinyl]-morpholine (55949-66-1) → N-(4-chlorobenzoyl)morpholine (19202-04-1)

Guidance literature:

With tris(2 2'-bipyridyl)ruthenium(II) chloride hexahydrate; oxygen; caesium carbonate; In acetonitrile; at 20 ℃; for 16h; Irradiation; Inert atmosphere;

DOI:10.1055/s-0034-1378205

Reference yield: 98.0%

morpholine (110-91-8,99108-56-2) + ethyl 4-chlorobenzoate (7335-27-5) → N-(4-chlorobenzoyl)morpholine (19202-04-1)

Guidance literature:

morpholine; With diisobutylaluminium hydride; In tetrahydrofuran; hexane; at 0 ℃; for 3h; Inert atmosphere;

ethyl 4-chlorobenzoate; In tetrahydrofuran; hexane; at 0 ℃; for 0.166667h; Inert atmosphere;

DOI:10.1016/j.tet.2014.03.045

upstream raw materials:

4-(4-chloro-thiobenzoyl)-morpholine

benzenecarbothioamide

morpholine

2,4-dinitrophenyl 4-chlorobenzoate

Downstream raw materials:

(4-butylphenyl)-4-morpholinylmethanone

(4-morpholinophenyl)phenylmethanone

4-benzoylmorpholine

(4-isopropylphenyl)(morpholino)methanone

Refernces

• 1、 Singh, Ashmita,Narula, Anudeep Kumar. "Copper and N-Heterocyclic Carbene-Catalyzed Oxidative Amidation of Aldehydes with Amines". supporting information. p. 718 - 722. Retrieved 2021/02/26.
• 2、 Rerkrachaneekorn, Tanawat,Tankam, Theeranon,Sukwattanasinitt, Mongkol,Wacharasindhu, Sumrit. "NaI-mediated oxidative amidation of benzyl alcohols/aromatic aldehydes to benzamides via electrochemical reaction". supporting information. . Retrieved 2021/04/15.