Nalmefene

Base Information Edit

Chemical Name:Nalmefene
CAS No.:55096-26-9
Molecular Formula:C₂₁H₂₅NO₃
Molecular Weight:339.434
Hs Code.:
European Community (EC) Number:637-223-3
UNII:TOV02TDP9I
DSSTox Substance ID:DTXSID8023347
Nikkaji Number:J23.288B
Wikipedia:Nalmefene
Wikidata:Q4353252
NCI Thesaurus Code:C61855
RXCUI:31479
Pharos Ligand ID:MJV3Z58X5UJA
Metabolomics Workbench ID:149690
ChEMBL ID:CHEMBL982
Mol file:55096-26-9.mol

Synonyms:6-desoxy-6-methylenenaltrexone;nalmefene;nalmefene hydrochloride;opvee;Revex;Selincro

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Nalmefene Edit

Chemical Property:

Melting Point:182-185?C
Boiling Point:507.9±50.0 °C(Predicted)
PKA:pKa 7.63(H2O) (Uncertain)
PSA：52.93000
Density:1.38±0.1 g/cm3(Predicted)
LogP:2.45040
Storage Temp.:2-8°C
Solubility.:Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly), Methanol (Sl
XLogP3:2.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:339.18344366
Heavy Atom Count:25
Complexity:618

Purity/Quality:

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Drug Classes:Opioid Antagonists
Canonical SMILES:C=C1CCC2(C3CC4=C5C2(C1OC5=C(C=C4)O)CCN3CC6CC6)O
Isomeric SMILES:C=C1CC[C@]2([C@H]3CC4=C5[C@]2([C@H]1OC5=C(C=C4)O)CCN3CC6CC6)O
Recent ClinicalTrials:Title: Effect of Opioid Receptor Modulation on Alcohol Self-Administration and Neural Response to Alcohol Cues in Heavy Drinkers: Role of OPRM1 Gene Variation
Recent EU Clinical Trials:Evaluation du nalméfène dans les troubles du contr?le des impulsions chez des patients ayant une maladie de Parkinson : une étude thérapeutique prospective ouverte
Recent NIPH Clinical Trials:Efficacy and safety of Nalmefene in alcohol-dependent patients with chronic liver disease
Uses A structural analog of Naltrexone (N285780) with opiate antagonist activity used in pharmaceutical treatment of alcoholism. Other pharmacological applications of this compound aim to reduce food cravings, drug abuse and pulmonary disease in affected individuals. Used as an opioid-induced tranquilizer on large animals in the veterinary industry. Narcotic antagonist. A structural labelled analog of Naltrexone (N285780) with opiate antagonist activity used in pharmaceutical treatment of alcoholism. Other pharmacological applications of this compound aim to reduce f ood cravings, drug abuse and pulmonary disease in affected individuals. Used as an opioid-induced tranquilizer on large animals in the veterinary industry. Narcotic antagonist. opioid antagonists therapeutic for alcohol dependence
Therapeutic Function Antagonist to narcotics
Biological Functions Nalmefene (Revex) is a long-acting injectable pure opioid antagonist recently introduced in the United States. It binds all opioid receptors and reverses the effects of opioid agonists at those receptors.The onset of action is 2 minutes after IV administration. Hepatic metabolism is slow and occurs via glucuronide conjugation to inactive metabolites. Its half-life of 11 hours is about 5 times that of naloxone. Indications include use in postoperative settings to reverse respiratory depression and in opioid overdose. Due to the long duration of action of nalmefene, however, naloxone may be preferred for treatment of overdose because it produces a shorter duration of withdrawal effects.

Technology Process of Nalmefene

There total 3 articles about Nalmefene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: