Oxirane-2-carboxylic acid

Base Information

• Chemical Name: Oxirane-2-carboxylic acid
• CAS No.: 503-11-7
• Molecular Formula: C3H4O3
• Molecular Weight: 88.063
• Hs Code.: 2918990090
• European Community (EC) Number: 207-961-7
• DSSTox Substance ID: DTXSID70964569
• Nikkaji Number: J82.101B
• Wikipedia: Glycidic_acid
• Wikidata: Q15411014
• ChEMBL ID: CHEMBL35308
• Mol file: 503-11-7.mol

Synonyms:ethoxypropionic acid;glycidic acid

Chemical Property of Oxirane-2-carboxylic acid

Chemical Property:

• Vapor Pressure: 0.00876mmHg at 25°C
• Melting Point: 196 °C (decomp)
• Refractive Index: 1.511
• Boiling Point: 246.5 °C at 760 mmHg
• PKA: 3.59±0.20(Predicted)
• Flash Point: 122.8 °C
• PSA: 49.83000
• Density: 1.557g/cm³
• LogP: -0.53020
• XLogP3: -0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 88.016043985
• Heavy Atom Count: 6
• Complexity: 78.1

Purity/Quality:

98%,99%, ^*data from raw suppliers

Oxirane-?2-?carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(O1)C(=O)O
• Uses: Oxirane-?2-?carboxylic Acid is used as reactant in the synthesis of glutathione peptidomimetics as components of antiparkinson prodrugs.

Technology Process of Oxirane-2-carboxylic acid

There total 13 articles about Oxirane-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

oxiranyl-methanol (556-52-5) → glycidic acid (503-11-7)

Guidance literature:

With sodium periodate; ruthenium trichloride; In water; acetonitrile; at 20 ℃; for 2h;

Reference yield:

acrylic acid (79-10-7) → glycidic acid (503-11-7)

Guidance literature:

With hypochloric acid; Behandeln des Reaktionsprodukts mit alkoh. Kali;

Reference yield:

3-chloro-2-hydroxypropanoic acid (1713-85-5) → glycidic acid (503-11-7)

Guidance literature:

With -base; dl-glycidic acid; Kinetik;

upstream raw materials:

acrylic acid

3-chloro-2-hydroxypropanoic acid

acide 2-bromo-3-hydroxy propanoique

acrolein

Downstream raw materials:

glyceric acid

(R,S)-3-bromo-2-hydroxypropanoic acid

erythro-9,10-dihydroxystearic acid

3-chloro-2-hydroxypropanoic acid

Refernces

• 1、 Zhou, Zhuohong,Dai, Guoyong,Ru, Shi,Yu, Han,Wei, Yongge. "Highly selective and efficient olefin epoxidation with pure inorganic-ligand supported iron catalysts". supporting information. p. 14201 - 14205. Retrieved 2019/10/02.
• 2、 Awasthi, Anupam,Dipti,Singh. "Epoxidation of acrylic acid by tetraethylammonium chlorochromate in an aquo-acetic acid-A kinetic study". experimental part. p. 410 - 412. Retrieved 2011/11/07.