Benzaldehyde, 2-hydroxy-, [(2-hydroxyphenyl)methylene]hydrazone

Base Information

• Chemical Name: Benzaldehyde, 2-hydroxy-, [(2-hydroxyphenyl)methylene]hydrazone
• CAS No.: 959-36-4
• Molecular Formula: C14H12N2O2
• Molecular Weight: 240.261
• Hs Code.: 29039990
• European Community (EC) Number: 213-500-0
• DSSTox Substance ID: DTXSID40862487
• Mol file: 959-36-4.mol

Synonyms:Salicylaldehyde azine;959-36-4;Salicylaldazine;Benzaldehyde, 2-hydroxy-, [(2-hydroxyphenyl)methylene]hydrazone;Salicylalazine;2-[[(2-hydroxyphenyl)methylidenehydrazinylidene]methyl]phenol;N,N'-bis(salicylidene)hydrazine;CBMicro_011302;DTXSID40862487;SY048277;FT-0633193;S0850;2,2'-(Hydrazinediylidenedimethanylylidene)diphenol

Chemical Property of Benzaldehyde, 2-hydroxy-, [(2-hydroxyphenyl)methylene]hydrazone

Chemical Property:

• Appearance/Colour: yellow solid
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 213 °C
• Refractive Index: 1.596
• Boiling Point: 399.078 °C at 760 mmHg
• Flash Point: 256.058 °C
• PSA: 65.18000
• Density: 1.172 g/cm³
• LogP: 2.55080
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• Water Solubility.: Soluble in dimethyl sulfoxide, methanol and ethyl acetate. Slightly soluble in water.
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 240.089877630
• Heavy Atom Count: 18
• Complexity: 274

Purity/Quality:

99% ^*data from raw suppliers

Salicylaldehyde Azine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:
• Hazard Codes: R36/37/38:
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-60-37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C=NN=CC2=CC=CC=C2O)O
• Uses: Salicylaldehyde azine is used in the preparation of 2-oxo-2H-1-benzopyran-3-carboxylic acid 2-(2-oxo-2H-1-benzopyran-3-carbonyl)hydrazide by reacting with propadienedione . It has anthelmintic activity. Hydrazone derivative with anthelminthic activity.

Technology Process of Benzaldehyde, 2-hydroxy-, [(2-hydroxyphenyl)methylene]hydrazone

There total 69 articles about Benzaldehyde, 2-hydroxy-, [(2-hydroxyphenyl)methylene]hydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-methyl-benzyl alcohol (89-95-2) → salicyaldehyde azine (959-36-4)

Guidance literature:

With sodium acetate; calcium chloride; hydrazinium sulfate; for 0.0111111h; microwave irradiation;

Reference yield: 92.0%

3,7-bis(2-hydrazonoethy)-(10-ethylphenothiazine) (909391-35-1) + salicylaldehyde (90-02-8) → salicyaldehyde azine (959-36-4)

Guidance literature:

In methanol; for 0.666667h; Reflux;

Reference yield: 89.0%

hydrazone of 2-acetylbenzofuran (94511-04-3) + salicylaldehyde (90-02-8) → 1-(benzo[b]furan-2-yl)ethanone (1646-26-0) + salicylaldazine (959-36-4,41097-51-2)

Guidance literature:

With hydrogenchloride; In ethanol; for 0.5h; Heating;

upstream raw materials:

salicylaldehyde semicarbazone

salicylaldehyde

2-Hydroxybenzoylhydrazine

N-(4-bromophenyl)-2-oxo-2H-chromene-3-carboxamide

Downstream raw materials:

4,4'-(2,2'-(1E,1'E)-hydrazine-1,2-diylidenebis(methan-1-yl-1-ylidene)bis(2,1-phenylene))bis(oxy)diphthalonitrile

1,5-di-o-hydroxyphenyl-2H,6H-perhydrotriazolo-[1,2-a]triazole-3,7-dithione

((1E,1'E)-hydrazine-1,2-diylidene bis(methanylylidene))bis(2,1-phenylene) diacetate

Refernces

• 1、 Ran, Jing-Wen,Liu, Shao-Wen,Wu, Peng,Pei, Jun. "Efficient photocatalytic properties of a dinuclear iron complex with bis[2-hydroxybenzaldehyde]hydrazonate ligand". . p. 373 - 375. Retrieved 2013.
• 2、 Xu, Xiangyu,Qiao, Jinping,Deng, Xuebin,Na, Na,Ouyang, Jin. "Salicylaldehyde azine cluster formation observed by cold-spray ionization mass spectrometry". . p. 961 - 968. Retrieved 2013.
• 3、 Xie, De-Xun,Ran, Zhao-Jin,Jin, Zhen,Zhang, Xiao-Bing,An, De-Lie. "A simple fluorescent probe for Zn(II) based on the aggregation-induced emission". . p. 495 - 499. Retrieved 2013.
• 4、 Li, Fan-fang,Chen, Hong-Yan,Jin, Yi,Zhao, Qi-Hua,Xie, Ming-Jin. "Synthesis, X-Ray Structure and In Vitro Cytotoxic Activity of a New Dinuclear Cobalt(III) Complex with Diazine Ligands". . p. 889 - 892. Retrieved 2018.
• 5、 Yousaf, Muhammad,Pervaiz, Muhammad,Jabbar, Abdul,Zahoor, Ameer Fawad,Bokhari, Tanveer Hussain,Anjum, Anbreen,Sagir, Muhammad,Khan, Misbahul Ain,Ali, Kulsoom Ghulam,Ahmad, Sajjad,Zia-Ur-Rehman, Muhammad,Ashraf, Sadia,Qeureshi, Khurram Shehzad. "Synthesis, characterization and biological studies of Bis{μ-2,2'-[N,N'- diylbis (nitrilomethylidyne)]diphenolato}dicobalt(II) using triple component solvent system". . p. 2161 - 2164. Retrieved 2013.
• 6、 Rajewar,Dharmale,Pingalkar. "Synthesis and spectroscopic investigation of schiff base complexes of lanthanides (III)". . p. 2865 - 2868. Retrieved 2015.
• 7、 Deng, Zhepeng,Ding, Wenmin,Guo, Geng,Jia, Yuehui,Li, Juan,Sun, Yinxia. "A novel and simple fluorescent chemical sensor SX based on AIE for relay recognition of Zn2+ and Cu2+ in aqueous system and analysis in logic gates". . . Retrieved 2021/12/27.
• 8、 -. "METHODS OF FORMING IMINES, IMINE-RELATED AND IMINE-DERIVED COMPOUNDS USING GREEN SOLVENTS". Paragraph 0194-0197. . Retrieved 2021/10/22.