CID 16205120

Base Information

• Chemical Name: CID 16205120
• CAS No.: 40600-13-3
• Molecular Formula: C13H17ClN2O
• Molecular Weight: 216.2789
• Mol file: 40600-13-3.mol

Synonyms:

Chemical Property of CID 16205120

Chemical Property:

• Vapor Pressure: 1.53E-06mmHg at 25°C
• Boiling Point: 409.5 °C at 760 mmHg
• Flash Point: 201.4 °C
• PSA: 33.62000
• Density: 1.25 g/cm³
• LogP: 2.51090
• Storage Temp.: Store at RT
• Solubility.: H2O: >35 mg/mL
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 252.1029409
• Heavy Atom Count: 17
• Complexity: 263

Purity/Quality:

98%,99%, ^*data from raw suppliers

Cirazoline hydrochloride ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CC1C2=CC=CC=C2OCC3=[NH+]CCN3.[Cl-]
• Description: Cirazoline is an α1-adrenergic receptor (α1-AR) agonist (Kis = 120, 960, and 660 nM for recombinant α1A-, α1B-, and α1D-ARs, respectively, in CHO cell membranes). It acts as a full agonist at α1A- and a partial agonist at α1B- and α1D-ARs in vitro (EC50s = 70.7, 79.4, and 239.8 nM, respectively). It also acts as an antagonist at α2-ARs with a pA2 value of 7.56 to inhibit the norepinephrine-induced twitch response in isolated pig ileum. Cirazoline (0.01-1 μg/kg) decreases blood pressure when administered via microinjection to the nucleus reticularis lateralis (NRL) of anesthetized normotensive cats. It enhances spatial memory and reduces depressive- and anxiety-like behavior in mice when administered at a concentration of 10 mg/L in drinking water for 2-9 months. It also enhances performance in the variable delayed response task in aged rhesus monkeys at high doses of 1-10 μg/kg but impairs performance at lower doses of 0.01-1 μg/kg.
• Uses: Cirazoline hydrochloride has been used to activate the α1-noradrenergic receptors and to study the inhibitory effect of neurokinin1 (NK1) antagonists on respiratory activity using the brainstem transverse slice.