N-CYCLOHEXYL 3-NITROBENZENESULFONAMIDE

Base Information

• Chemical Name: N-CYCLOHEXYL 3-NITROBENZENESULFONAMIDE
• CAS No.: 93125-79-2
• Molecular Formula: C₁₂H₁₆N₂O₄S
• Molecular Weight: 284.336
• Mol file: 93125-79-2.mol

Synonyms:NSC 61574

Chemical Property of N-CYCLOHEXYL 3-NITROBENZENESULFONAMIDE

Chemical Property:

• Vapor Pressure: 4.35E-08mmHg at 25°C
• Boiling Point: 444.2°Cat760mmHg
• Flash Point: 222.5°C
• PSA: 100.37000
• Density: 1.35g/cm³
• LogP: 4.20070

Purity/Quality:

98%min ^*data from raw suppliers

N-Cyclohexyl-3-nitrobenzenesulfonamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-CYCLOHEXYL 3-NITROBENZENESULFONAMIDE

There total 1 articles about N-CYCLOHEXYL 3-NITROBENZENESULFONAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

cyclohexylamine (108-91-8,157973-60-9) + 3-nitrobenzenesulphonyl chloride (121-51-7) → N-cyclohexyl-3-nitrobenzenesulfonamide (93125-79-2)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/acs.jmedchem.8b00654

Reference yield:

N-cyclohexyl-3-nitrobenzenesulfonamide (93125-79-2) → N-[3-(cyclohexylsulfamoyl)phenyl]benzamide

Guidance literature:

Multi-step reaction with 2 steps

1.1: palladium on activated charcoal; hydrogen / methanol / 1 h / 20 °C / 760.05 Torr

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 20 °C

With palladium on activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/acs.jmedchem.8b00654

Reference yield:

N-cyclohexyl-3-nitrobenzenesulfonamide (93125-79-2) → N-[3-(cyclohexylsulfamoyl)phenyl]-4-fluorobenzamide

Guidance literature:

Multi-step reaction with 2 steps

1.1: palladium on activated charcoal; hydrogen / methanol / 1 h / 20 °C / 760.05 Torr

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 20 °C

With palladium on activated charcoal; hydrogen; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/acs.jmedchem.8b00654

upstream raw materials:

cyclohexylamine

3-nitrobenzenesulphonyl chloride

Refernces