CCRIS 6958

Base Information

• Chemical Name: CCRIS 6958
• CAS No.: 64507-38-6
• Molecular Formula: C10H6BrNO2
• Molecular Weight: 252.07
• Hs Code.: 2933499090
• Mol file: 64507-38-6.mol

Synonyms:6-Bromoquinoline-8-carboxylicacid;6-Bromo-8-quinolinecarboxylic acid;6-Bromo-8-quinolinecarboxylic;

Chemical Property of CCRIS 6958

Chemical Property:

• Vapor Pressure: 2.68E-08mmHg at 25°C
• Refractive Index: 1.709
• Boiling Point: 433.9 °C at 760 mmHg
• Flash Point: 216.2 °C
• PSA: 50.19000
• Density: 1.732 g/cm³
• LogP: 2.69550
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

6-Bromoquinoline-8-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CCRIS 6958

There total 4 articles about CCRIS 6958 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

6-bromo-8-bromomethylquinoline (926207-02-5) → 6-bromoquinoline-8-carboxylic acid (64507-38-6)

Guidance literature:

With cobalt(II) chloride hexahydrate; dihydrogen peroxide; acetic acid; copper(II) oxide; palladium dichloride; In water; at 115 ℃; for 8h;

Reference yield: 2.0%

glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) + 5-Bromo-2-aminobenzoic acid (5794-88-7) → 6-bromoquinoline-8-carboxylic acid (64507-38-6)

Guidance literature:

With sulfuric acid; iodine; at 65 - 140 ℃; for 6.5h;

Reference yield:

5-Bromo-2-aminobenzoic acid (5794-88-7) + acrolein (107-02-8,25068-14-8) → 6-bromoquinoline-8-carboxylic acid (64507-38-6)

Guidance literature:

With trifluorormethanesulfonic acid; oxygen; silver trifluoromethanesulfonate; In toluene; at 25 - 110 ℃; for 17h; under 775.743 Torr;

upstream raw materials:

glycerol

5-Bromo-2-aminobenzoic acid

6-bromo-8-bromomethylquinoline

acrolein

Refernces

• 1、 -. "BENZOPYRAZOLE COMPOUND USED AS RHO KINASE INHIBITOR". Paragraph 0414-0416. . Retrieved 2021/02/25.
• 2、 Weyer,Aumuller,Bander,Heerdt,Pfaff,Schweitzer,Weber. "Hypoglycemic quinoline 8 carboxamidoalkyl benzenesulfonamide derivatives". . p. 269 - 275. Retrieved 2007/10/08.