Palosuran

Base Information

• Chemical Name: Palosuran
• CAS No.: 540769-28-6
• Molecular Formula: C25H30N4O2
• Molecular Weight: 418.53
• UNII: ULD9ZKE457
• DSSTox Substance ID: DTXSID00202406
• Nikkaji Number: J2.917.197A
• Wikidata: Q27088242
• NCI Thesaurus Code: C66298
• Pharos Ligand ID: 1PAW74JKSQPV
• ChEMBL ID: CHEMBL567303
• Mol file: 540769-28-6.mol

Synonyms:1-(2-(4-benzyl-4-hydroxypiperidin-1-yl)ethyl)-3-(2-methylquinolin-4-yl)urea;1-(2-(4-benzyl-4-hydroxypiperidin-1-yl)ethyl)-3-(2-methylquinolin-4-yl)urea sulfate salt;ACT 058362;ACT-058362;ACT058362;palosuran

Chemical Property of Palosuran

Chemical Property:

• Boiling Point: 612.9±55.0 °C(Predicted)
• PKA: 12.95±0.43(Predicted)
• PSA: 77.49000
• Density: 1.235±0.06 g/cm3(Predicted)
• LogP: 4.13610
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 418.23687621
• Heavy Atom Count: 31
• Complexity: 572

Purity/Quality:

99% ^*data from raw suppliers

ACT058362(Palosuran) >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC2=CC=CC=C2C(=C1)NC(=O)NCCN3CCC(CC3)(CC4=CC=CC=C4)O
• Description: Palosuran is an antagonist of the urotensin II receptor (UTR; IC50s = 3.6 and 1,475 nM for CHO cell membranes expressing human and rat recombinant receptors, respectively). It inhibits contraction of isolated rat aortic rings induced by urotensin II (Item Nos. 24711 | 24753) in a concentration-dependent manner. Palosuran (300 mg/kg twice per day) reduces plasma endothelin-1 , urotensin II, and TGF-β1 levels, as well as the main pulmonary arterial pressure and right ventricular hypertrophy index in a rat model of pulmonary arterial hypertension (PAH) induced by monocrotaline . Palosuran (300 mg/kg per day) reduces serum glucose, cholesterol, and triglyceride levels and increases survival in a rat model of diabetes induced by streptozotocin (STZ; ). It also decreases albuminuria and global kidney lesion scores in STZ-induced diabetic rats.