Technology Process of 1-Cyclopentene-1-carboxylic acid,
4-(6-chloro-9H-purin-9-yl)-3-[(4-nitrobenzoyl)oxy]-, methyl ester,
(3R,4R)-
There total 6 articles about 1-Cyclopentene-1-carboxylic acid,
4-(6-chloro-9H-purin-9-yl)-3-[(4-nitrobenzoyl)oxy]-, methyl ester,
(3R,4R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: chiral modular ligand; Et3N / Pd3dba3*CHCl3 / tetrahydrofuran / 5 h / 20 °C
2: 95 percent / PPh3; Et3N / Pd2dba3*CHCl3 / tetrahydrofuran / 12 h / 20 °C
3: 73 percent / MCPBA / CH2Cl2 / 44 h / 20 °C
4: 67 percent / DBU; ozone / tetrahydrofuran / 3 h / -78 - 20 °C
5: 62 percent / PPh3; DEAD / tetrahydrofuran / 6 h / 0 °C
With
chiral modular ligand; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; diethylazodicarboxylate;
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; (dba)3Pd3*CHCl3;
In
tetrahydrofuran; dichloromethane;
1: asymmetric allylic alkylation / 2: Alkylation / 3: Epoxidation / 4: oxidative esterification / 5: Mitsunobu reaction;
DOI:10.1021/ja9938837
- Guidance literature:
-
Multi-step reaction with 5 steps
1: chiral modular ligand; Et3N / Pd3dba3*CHCl3 / tetrahydrofuran / 5 h / 20 °C
2: 95 percent / PPh3; Et3N / Pd2dba3*CHCl3 / tetrahydrofuran / 12 h / 20 °C
3: 73 percent / MCPBA / CH2Cl2 / 44 h / 20 °C
4: 67 percent / DBU; ozone / tetrahydrofuran / 3 h / -78 - 20 °C
5: 62 percent / PPh3; DEAD / tetrahydrofuran / 6 h / 0 °C
With
chiral modular ligand; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; diethylazodicarboxylate;
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; (dba)3Pd3*CHCl3;
In
tetrahydrofuran; dichloromethane;
1: asymmetric allylic alkylation / 2: Alkylation / 3: Epoxidation / 4: oxidative esterification / 5: Mitsunobu reaction;
DOI:10.1021/ja9938837