AKOS B013938

Base Information

• Chemical Name: AKOS B013938
• CAS No.: 10514-62-2
• Molecular Formula: C10H11 N O5
• Molecular Weight: 225.2
• Hs Code.: 2918990090
• Mol file: 10514-62-2.mol

Synonyms:Propionicacid, 2-methyl-2-(o-nitrophenoxy)- (7CI,8CI);2-Methyl-2-(o-nitrophenoxy)propionic acid

Chemical Property of AKOS B013938

Chemical Property:

• Vapor Pressure: 1.28E-06mmHg at 25°C
• Boiling Point: 385.1°C at 760 mmHg
• Flash Point: 186.7°C
• PSA: 92.35000
• Density: 1.328g/cm³
• LogP: 2.36000

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Methyl-2-(2-nitrophenoxy)propanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AKOS B013938

There total 8 articles about AKOS B013938 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

2-methyl-2-(2-nitrophenoxy)propionic acid ethyl ester (344438-62-6) → 2-Methyl-2-(2-nitrophenoxy)propanoic Acid (10514-62-2)

Guidance literature:

With potassium hydroxide; In ethanol; for 2h; Heating;

DOI:10.1055/s-2004-837302

Reference yield:

2-chloro-2-methylpropanoic acid (594-58-1) + 2-hydroxynitrobenzene (88-75-5,78813-12-4) → 2-Methyl-2-(2-nitrophenoxy)propanoic Acid (10514-62-2)

Guidance literature:

With potassium carbonate; In acetone;

DOI:10.1021/jo01346a027

Reference yield:

2-hydroxynitrobenzene (88-75-5,78813-12-4) → 2-Methyl-2-(2-nitrophenoxy)propanoic Acid (10514-62-2)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃, polyethyleneglycol / 6 h / 100 °C

2: KOH / ethanol / 4 h / Heating

With potassium hydroxide; potassium carbonate; polyethyleneglycol; In ethanol;

upstream raw materials:

2-methyl-2-phenoxypropionic acid

ethyl 2-bromoisobutyrate

sodium o-nitrophenate

2-methyl-2-(2-nitrophenoxy)propionic acid ethyl ester

Downstream raw materials:

2,2-dimethyl-4-hydroxy-2H-1,4-benzoxazin-3(4H)-one

1-Bromo-3-methyl-3-(2-nitrophenoxy)butan-2-one

1-Succinimido-3-methyl-3-(2-nitrophenoxy)butan-2-one

2-methyl-2-(2-nitrophenoxy)propionamide

Refernces

• 1、 Reddy Sastry,Srinivasa Rao,Krishnan,Rastogi,Jain,Verma,Tripathi,Singh,Seshagiri Rao,Kaushal. "Synthesis of 6-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-2H-1,4-benzoxazin-3(4H)-ones as possible cardiotonic agents". . p. 882 - 884. Retrieved 2007/10/02.
• 2、 Johnson,Panetta,Smith. "Nonenzymatic conversion of penicillins to 6-aminopenicillanic acid.". . p. 2560 - 2564. Retrieved 2007/10/06.