[(chlorogermanediyl)dimethanetriyl]tetrakis(trimethylsilane)

Base Information

• Chemical Name: [(chlorogermanediyl)dimethanetriyl]tetrakis(trimethylsilane)
• CAS No.: 7237-52-7
• Molecular Formula: C₂₁H₂₆N₂O₂*ClH
• Molecular Weight: 374.911
• Mol file: 7237-52-7.mol

Synonyms:Coronaridine,hydrochloride (6CI,7CI); Coronaridine, monohydrochloride, (-)- (8CI);Ibogamine-18-carboxylic acid, methyl ester, monohydrochloride (9CI);6,9-Methano-5H-pyrido[1',2':1,2]azepino[4,5-b]indole, ibogamine-18-carboxylicacid deriv.; (-)-Coronaridine hydrochloride; (-)-Coronaridine monohydrochloride

Chemical Property of [(chlorogermanediyl)dimethanetriyl]tetrakis(trimethylsilane)

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [(chlorogermanediyl)dimethanetriyl]tetrakis(trimethylsilane)

There total 5 articles about [(chlorogermanediyl)dimethanetriyl]tetrakis(trimethylsilane) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

catharinthine (2468-21-5) → (+)-coronaridine hydrochloride (28888-46-2,4503-12-2,7237-52-7)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogen; platinum(IV) oxide / methanol / 0.08 h / 760.05 Torr / Inert atmosphere

2: [Ir(C₆H₂F₂-C₅H₃NCF₃)₂(4,4′-di-tert-butyl-2,2′-dipyridyl)]⁺ / methanol / 50 °C / Inert atmosphere; Flow reactor; UV-irradiation

3: trifluoroacetic acid / toluene / 3 h / 120 °C / Inert atmosphere

4: hydrogenchloride / diethyl ether / Inert atmosphere

With hydrogenchloride; platinum(IV) oxide; [Ir(C₆H₂F₂-C₅H₃NCF₃)₂(4,4′-di-tert-butyl-2,2′-dipyridyl)]⁺; hydrogen; trifluoroacetic acid; In methanol; diethyl ether; toluene;

DOI:10.1021/ja506170g

Reference yield:

methyl 4-cyano-5-ethyl-1,4,7,8,9,10-hexahydro-2H-3,7-methanoazacycloundecino<5,4-b>indole-9-carboxylate (136118-90-6) → (+)-coronaridine hydrochloride (28888-46-2,4503-12-2,7237-52-7)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen; palladium 10% on activated carbon / methanol / 0.42 h / Inert atmosphere

2: trifluoroacetic acid / toluene / 3 h / 120 °C / Inert atmosphere

3: hydrogenchloride / diethyl ether / Inert atmosphere

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; trifluoroacetic acid; In methanol; diethyl ether; toluene;

DOI:10.1021/ja506170g

Reference yield:

(+)-dihydrocatharanthine (38542-83-5) → (+)-coronaridine hydrochloride (28888-46-2,4503-12-2,7237-52-7)

Guidance literature:

Multi-step reaction with 3 steps

1: [Ir(C₆H₂F₂-C₅H₃NCF₃)₂(4,4′-di-tert-butyl-2,2′-dipyridyl)]⁺ / methanol / 50 °C / Inert atmosphere; Flow reactor; UV-irradiation

2: trifluoroacetic acid / toluene / 3 h / 120 °C / Inert atmosphere

3: hydrogenchloride / diethyl ether / Inert atmosphere

With hydrogenchloride; [Ir(C₆H₂F₂-C₅H₃NCF₃)₂(4,4′-di-tert-butyl-2,2′-dipyridyl)]⁺; trifluoroacetic acid; In methanol; diethyl ether; toluene;

DOI:10.1021/ja506170g

upstream raw materials:

(+)-dihydrocatharanthine

catharinthine

(+)-coronaridine

methyl 4-cyano-5-ethyl-1,4,7,8,9,10-hexahydro-2H-3,7-methanoazacycloundecino<5,4-b>indole-9-carboxylate

Refernces