3-Bromophenylhydrazine hydrochloride

Base Information

• Chemical Name: 3-Bromophenylhydrazine hydrochloride
• CAS No.: 27246-81-7
• Molecular Formula: C6H7BrN2^.HCl
• Molecular Weight: 223.5
• Hs Code.: 29280000
• European Community (EC) Number: 248-362-0
• DSSTox Substance ID: DTXSID40181701
• Mol file: 27246-81-7.mol

Synonyms:3-Bromophenylhydrazine hydrochloride;27246-81-7;(3-bromophenyl)hydrazine hydrochloride;3-BROMOPHENYLHYDRAZINE HCL;(3-Bromophenyl)hydrazine HCl;(m-Bromophenyl)hydrazine hydrochloride;(3-Bromophenyl)hydrazine, HCl;EINECS 248-362-0;Hydrazine, (3-bromophenyl)-, monohydrochloride;1-(3-bromophenyl)hydrazine hydrochloride;HYDRAZINE, (m-BROMOPHENYL)-, MONOHYDROCHLORIDE;(3-bromophenyl)hydrazine;hydrochloride;3-Bromophenylhydrazinehydrochloride;(3-Bromophenyl)hydrazinehydrochloride;(3-bromophenyl)hydrazine,hydrochloride;SCHEMBL133388;DTXSID40181701;5-bromophenylhydrazine hydrochloride;3-bromophenyl hydrazine hydrochloride;MFCD00012933;AKOS001475941;AC-7109;CS-W007915;GS-3546;LS-76457;3-Bromophenylhydrazine hydrochloride, 98%;3-bromophenylhydrazine hydrochloric acid salt;AM20061081;B3847;FT-0638685;EN300-15189;J-501191;F2121-0398;Z118530090;3-Bromophenylhydrazine hydrochloride, technical, >=96% (AT)

Chemical Property of 3-Bromophenylhydrazine hydrochloride

Chemical Property:

• Appearance/Colour: off-white to light brown powder
• Vapor Pressure: 0.00272mmHg at 25°C
• Melting Point: 227-231 °C (dec.)(lit.)
• Refractive Index: 1.68
• Boiling Point: 286 °C at 760 mmHg
• Flash Point: 126.7 °C
• PSA: 38.05000
• Density: 1.666g/cm³
• LogP: 3.31000
• Storage Temp.: Room temperature.
• Sensitive.: Hygroscopic
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 221.95594
• Heavy Atom Count: 10
• Complexity: 87.1

Purity/Quality:

99% ^*data from raw suppliers

3-Bromophenylhydrazine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi, C
• Hazard Codes: C,Xi
• Statements: 34-36/37/38
• Safety Statements: 26-36/37/39-45-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)Br)NN.Cl
• Uses: A phenylhydrazone derivative with fungicidal activity. 3-Bromophenylhydrazine hydrochloride was used to prepare 6-(3-Bromophenylhydrazono)-7,8,9,11-tetrahydropyrido [2,1- b]quinazoline-11-one.

Technology Process of 3-Bromophenylhydrazine hydrochloride

There total 2 articles about 3-Bromophenylhydrazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1,3-dibromobenzene (108-36-1) → 3-bromophenylhydrazine hydrochloride (27246-81-7)

Guidance literature:

1,3-dibromobenzene; With potassium phosphate; copper(l) iodide; N,N′-bis(2,6-dimethylphenyl)oxalamide; cetyltrimethylammonim bromide; In water; at 80 ℃; for 0.25h; Schlenk technique; Inert atmosphere; Sealed tube;

With hydrazine hydrate; In water; at 80 ℃; Inert atmosphere; Schlenk technique; Sealed tube;

With hydrogenchloride; In water; pH=3 - 4; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1002/cjoc.201800326

Reference yield: 75.0%

m-Bromoaniline (591-19-5) → 3-bromophenylhydrazine hydrochloride (27246-81-7)

Guidance literature:

m-Bromoaniline; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 1h;

With hydrogenchloride; tin(II) chloride dihdyrate; In water; at 0 - 20 ℃; for 3h;

Reference yield: 100.0%

3-bromophenylhydrazine hydrochloride (27246-81-7) + 2-[1-ethoxy-meth-(Z)-ylidene]-4,4,4-trifluoro-3-oxo-butyric acid ethyl ester (1048670-08-1) → 1-(3-bromo-phenyl)-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid ethyl ester

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In ethanol; at 20 ℃; for 16h;

upstream raw materials:

m-Bromoaniline

1,3-dibromobenzene

Downstream raw materials:

3-{1-[(3-Bromo-phenyl)-hydrazono]-ethyl}-4-hydroxy-chromen-2-one

phenyl-(5-phenyl-[1,2,4]oxadiazol-3-yl)-methanone (3-bromo-phenyl)-hydrazone

N-(3-Bromo-phenyl)-N'-[1-phenyl-1-(5-phenyl-[1,2,4]oxadiazol-3-yl)-meth-(Z)-ylidene]-hydrazine

1-(3-Bromo-phenyl)-5-(2-nitro-phenyl)-3-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester

Refernces

• 1、 Lombardi, Lorenzo,Bellini, Daniele,Bottoni, Andrea,Calvaresi, Matteo,Monari, Magda,Kovtun, Alessandro,Palermo, Vincenzo,Melucci, Manuela,Bandini, Marco. "Allylic and Allenylic Dearomatization of Indoles Promoted by Graphene Oxide by Covalent Grafting Activation Mode". supporting information. p. 10427 - 10432. Retrieved 2020/07/24.
• 2、 Zhai, Min'an,Wang, Long,Liu, Shiyuan,Wang, Lijing,Yan, Peng,Wang, Junfang,Zhang, Jingbo,Guo, Haifei,Guan, Qi,Bao, Kai,Wu, Yingliang,Zhang, Weige. "Synthesis and biological evaluation of (1-aryl-1H-pyrazol-4-yl) (3,4,5-trimethoxyphenyl)methanone derivatives as tubulin inhibitors". . p. 137 - 147. Retrieved 2018/07/13.