4-(4-Fluorophenyl)piperidin-4-ol

Base Information

• Chemical Name: 4-(4-Fluorophenyl)piperidin-4-ol
• CAS No.: 3888-65-1
• Molecular Formula: C11H14FNO
• Molecular Weight: 195.237
• Hs Code.: 2933399090
• European Community (EC) Number: 223-431-8
• NSC Number: 90449
• DSSTox Substance ID: DTXSID60192132
• Nikkaji Number: J217.737D
• Wikidata: Q83064760
• Mol file: 3888-65-1.mol

Synonyms:A-6550;A6550;N-acetyl-3,7-dihydroxyphenoxazine

Chemical Property of 4-(4-Fluorophenyl)piperidin-4-ol

Chemical Property:

• Vapor Pressure: 0.000212mmHg at 25°C
• Melting Point: 116.4-117.6℃
• Boiling Point: 313.4 °C at 760 mmHg
• Flash Point: 143.3 °C
• PSA: 32.26000
• Density: 1.173 g/cm³
• LogP: 1.72550
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 195.105942232
• Heavy Atom Count: 14
• Complexity: 184

Purity/Quality:

4-(4-Fluorophenyl)-4-piperidinol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

Useful:

• Canonical SMILES: C1CNCCC1(C2=CC=C(C=C2)F)O
• Uses: 4-(4-Fluorophenyl)-4-piperidinol serves as one of the reagents for the discovery of AZD3514 as androgen receptor down regulator for treatment of advanced prostrate cancer. Also functions as an intermediate in the synthesis of haloperidol (H103700), an antidyskinetic; antipsychotic. neuroprotective product.

Technology Process of 4-(4-Fluorophenyl)piperidin-4-ol

There total 10 articles about 4-(4-Fluorophenyl)piperidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

tert-butyl 4-hydroxy-4-(4-fluorophenyl)-1-piperidinecarboxylate (553631-05-3) → 4-(4-fluorophenyl)piperidin-4-ol (3888-65-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;

DOI:10.1021/acs.jmedchem.9b00864

Reference yield: 87.0%

1-(Ethoxycarbonyl)-4-(4-fluorophenyl)piperidin-4-ol (82387-58-4) → 4-(4-fluorophenyl)piperidin-4-ol (3888-65-1)

Guidance literature:

With potassium hydroxide; In ethanol; for 2h; Heating;

DOI:10.1135/cccc19820636

Reference yield: 82.0%

1-benzyl-4-(4-fluorophenyl)-4-hydroxypiperidine (163631-02-5) → 4-(4-fluorophenyl)piperidin-4-ol (3888-65-1)

Guidance literature:

With 10 wt% Pd(OH)2 on carbon; hydrogen; In methanol;

upstream raw materials:

4-Brom-4-(4-fluor-phenyl)-piperidin

1-(Ethoxycarbonyl)-4-(4-fluorophenyl)piperidin-4-ol

4-flourophenylmagnesium bromide

N-ethoxycarbonyl-4-piperidone

Downstream raw materials:

4-<4-(4-fluorophenyl)-4-hydroxy-1-piperidinyl>-1-(4-fluorophenyl)-1-butanone

SGT₅₄₂

{3-[4-(4-fluoro-phenyl)-4-hydroxy-piperidin-1-yl]-propyl}-carbamic acid tert-butyl ester

6-[2S*-(4-Hydroxy-4-(4-fluorophenyl)piperidino)-1S*-hydroxypropyl]-3, 4-dihydro-2(1H)-quinolone mesylate

Refernces

• 1、 -. "HEPATITIS B ANTIVIRAL AGENTS". . . Retrieved 2013/07/05.
• 2、 -. "DIPHENYLBUTYPIPERIDINE AUTOPHAGY INDUCERS". Page/Page column 7; 84-85. . Retrieved 2011/12/02.