2-OCTANOYLTHIOPHENE

Base Information

• Chemical Name: 2-OCTANOYLTHIOPHENE
• CAS No.: 30711-41-2
• Molecular Formula: C12H18OS
• Molecular Weight: 210.34
• Hs Code.: 2934999090
• Mol file: 30711-41-2.mol

Synonyms:2-Octanoylthiophene;

Chemical Property of 2-OCTANOYLTHIOPHENE

Chemical Property:

• Vapor Pressure: 0.000543mmHg at 25°C
• Refractive Index: 1.5200
• Boiling Point: 312 °C at 760 mmHg
• Flash Point: 142.5 °C
• PSA: 45.31000
• Density: 1.004 g/cm³
• LogP: 4.29130

Purity/Quality:

98%min ^*data from raw suppliers

1-Thiophen-2-yl-octan-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T,Xi
• Hazard Codes: T,Xi
• Safety Statements: S24/25:Avoid contact with skin and eyes.

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Octanoylthiophene is used in the synthesis of thiophenes.

Technology Process of 2-OCTANOYLTHIOPHENE

There total 9 articles about 2-OCTANOYLTHIOPHENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

thiophene (188290-36-0,8014-23-1,25233-34-5) + n-octanoic acid chloride (111-64-8) → 1-(thiophen-2-yl)octan-1-one (30711-41-2)

Guidance literature:

With aluminium trichloride; In benzene; at 0 - 20 ℃;

DOI:10.1039/a900075e

Reference yield: 80.0%

1-(thiophen-2-yl)-1-octyne (391669-53-7) → 1-(thiophen-2-yl)octan-1-one (30711-41-2)

Guidance literature:

With iron(III) sulphate monohydrate; acetic acid; at 80 ℃; for 22h; regioselective reaction; Mechanism;

DOI:10.1002/adsc.201900633

Reference yield: 78.0%

2-bromothiophene (1003-09-4) + Octanal (124-13-0) → 1-(thiophen-2-yl)octan-1-one (30711-41-2)

Guidance literature:

With pyrrolidine; tetrabutylammomium bromide; palladium diacetate; In N,N-dimethyl-formamide; at 100 ℃; for 10h; Molecular sieve; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.05.067

upstream raw materials:

thiophene

Octanoic acid

n-octanoic acid chloride

2-bromothiophene

Downstream raw materials:

dithieno[3, 4-b:3',4'-d]thiophene

2-octylthiophene

1-[2]thienyl-octan-1-one-(2,4-dinitro-phenylhydrazone)

Refernces

• 1、 Ghinato, Simone,Territo, Davide,Maranzana, Andrea,Capriati, Vito,Blangetti, Marco,Prandi, Cristina. "A Fast and General Route to Ketones from Amides and Organolithium Compounds under Aerobic Conditions: Synthetic and Mechanistic Aspects". supporting information. p. 2868 - 2874. Retrieved 2021/01/21.
• 2、 Antenucci, Achille,Flamini, Piergiorgio,Fornaiolo, Marco Valerio,Di Silvio, Sergio,Mazzetti, Sara,Mencarelli, Paolo,Salvio, Riccardo,Bassetti, Mauro. "Iron(III)-Catalyzed Hydration of Unactivated Internal Alkynes in Weak Acidic Medium, under Lewis Acid-Assisted Br?nsted Acid Catalysis". . p. 4517 - 4526. Retrieved 2019/08/26.