N-(4-Carboxy-3-hydroxyphenyl)maleimide

Base Information

• Chemical Name: N-(4-Carboxy-3-hydroxyphenyl)maleimide
• CAS No.: 19232-43-0
• Molecular Formula: C11H7NO5
• Molecular Weight: 233.18
• Hs Code.: 2925190090
• NSC Number: 59375
• UNII: H822IOP4G8
• DSSTox Substance ID: DTXSID30172820
• Nikkaji Number: J398.998D
• Wikidata: Q83042905
• ChEMBL ID: CHEMBL509675
• Mol file: 19232-43-0.mol

Synonyms:N-(4-carboxy-3-hydroxyphenyl)maleimide

Chemical Property of N-(4-Carboxy-3-hydroxyphenyl)maleimide

Chemical Property:

• Vapor Pressure: 5.06E-11mmHg at 25°C
• Refractive Index: 1.709
• Boiling Point: 505.1 °C at 760 mmHg
• Flash Point: 259.3 °C
• PSA: 94.91000
• Density: 1.651 g/cm³
• LogP: 0.58480
• Storage Temp.: ?20°C
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 233.03242232
• Heavy Atom Count: 17
• Complexity: 385

Purity/Quality:

99% ^*data from raw suppliers

4-MALEIMIDOSALICYLIC ACID Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=C(C=C1N2C(=O)C=CC2=O)O)C(=O)O

Technology Process of N-(4-Carboxy-3-hydroxyphenyl)maleimide

There total 2 articles about N-(4-Carboxy-3-hydroxyphenyl)maleimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

N-(3-hydroxy-4-methoxycarbonylphenyl)maleimide (439931-53-0) → N-(4-carboxy-3-hydroxyphenyl)maleimide (19232-43-0)

Guidance literature:

With hydrogenchloride; water; In acetic acid; at 100 ℃; for 8h;

DOI:10.1021/jm800869t

Reference yield:

→ N-(4-carboxy-3-hydroxyphenyl)maleimide (19232-43-0)

Guidance literature:

Maleamylazid, NaAc, Ac2O, HCl;

DOI:10.1515/bchm2.1975.356.2.1455

upstream raw materials:

N-(3-hydroxy-4-methoxycarbonylphenyl)maleimide

Refernces

• 1、 Trommer,Kolkenbrock,Pfeiderer. "Synthesis and properties of a new selective bifunctional cross linking reagent". . p. 1455 - 1458. Retrieved 2007/10/10.