2-(2-CHLOROBENZOYL)PYRIDINE

Base Information

• Chemical Name: 2-(2-CHLOROBENZOYL)PYRIDINE
• CAS No.: 1694-57-1
• Molecular Formula: C12H8 Cl N O
• Molecular Weight: 217.655
• Hs Code.: 2933399090
• Mol file: 1694-57-1.mol

Synonyms:Ketone,o-chlorophenyl 2-pyridyl (7CI,8CI); 2-Chlorophenyl 2-pyridyl ketone

Chemical Property of 2-(2-CHLOROBENZOYL)PYRIDINE

Chemical Property:

• Vapor Pressure: 3.59E-05mmHg at 25°C
• Melting Point: 52-54 °C
• Boiling Point: 353.4°Cat760mmHg
• PKA: 2.47±0.10(Predicted)
• Flash Point: 167.5°C
• PSA: 29.96000
• Density: 1.26g/cm³
• LogP: 2.96600
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

(2-chlorophenyl)(pyridin-2-yl)methanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-CHLOROBENZOYL)PYRIDINE

There total 12 articles about 2-(2-CHLOROBENZOYL)PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

α-(2-chlorophenyl)-2-pyridylmethanol (6238-67-1,112906-29-3,112966-25-3) → (2-chlorophenyl)(pyridin-2-yl)methanone (1694-57-1)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; for 9h;

DOI:10.1002/chem.201302997

Reference yield: 50.0%

phenyl(pyridin-2-yl)methanone (91-02-1) → (2-chlorophenyl)(pyridin-2-yl)methanone (1694-57-1)

Guidance literature:

With 1,3-dichloro-5,5-dimethylhydantoin; palladium diacetate; In 1,2-dichloro-ethane; at 90 ℃; for 12h;

Reference yield: 50.0%

2-bromo-pyridine (109-04-6) + methyl chlorobenzoate (610-96-8) → (2-chlorophenyl)(pyridin-2-yl)methanone (1694-57-1)

Guidance literature:

2-bromo-pyridine; With n-butyllithium; In tetrahydrofuran; diethyl ether; cyclohexane; at -85 - -10 ℃; for 0.25h;

methyl chlorobenzoate; In tetrahydrofuran; diethyl ether; cyclohexane; toluene; at -110 - 20 ℃; for 24h;

DOI:10.1021/ml5000228

upstream raw materials:

2-pyridyllithium

2-chloro-benzaldehyde

2-Cyanopyridine

2-bromo-1-chlorobenzene

Downstream raw materials:

2-[(2-chlorophenyl)(hydrazono)methyl]pyridine

3-(2-chlorophenyl)-[1,2,3]triazolo[1,5-a]pyridine

(E)-4-(2-chlorophenyl)-N,N-dimethyl-4-(2-pyridyl)but-3-en-1-ammonium trifluoroacetate

α-(2-chlorophenyl)-2-pyridylmethanol

Refernces

• 1、 Jin, Liang,Yao, Qi-Jun,Xie, Pei-Pei,Li, Ya,Zhan, Bei-Bei,Han, Ye-Qiang,Hong, Xin,Shi, Bing-Feng. "Atroposelective Synthesis of Axially Chiral Styrenes via an Asymmetric C–H Functionalization Strategy". supporting information. p. 497 - 511. Retrieved 2020/02/20.
• 2、 Wang, Baigui,Zhou, Haifeng,Lu, Guoren,Liu, Qixing,Jiang, Xiaolan. "Bifunctional Oxo-Tethered Ruthenium Complex Catalyzed Asymmetric Transfer Hydrogenation of Aryl N-Heteroaryl Ketones". supporting information. p. 2094 - 2097. Retrieved 2017/04/28.