Glycyl-d-leucine

Base Information

• Chemical Name: Glycyl-d-leucine
• CAS No.: 688-13-1
• Molecular Formula: C8H16N2O3
• Molecular Weight: 188.227
• Hs Code.: 2924199090
• DSSTox Substance ID: DTXSID001017042
• Nikkaji Number: J208.544E
• ChEMBL ID: CHEMBL53813
• Mol file: 688-13-1.mol

Synonyms:Glycyl-d-leucine;688-13-1;(R)-2-(2-Aminoacetamido)-4-methylpentanoic acid;H-Gly-D-Leu-OH;(2R)-2-[(2-aminoacetyl)amino]-4-methylpentanoic acid;Gly-D-Leu;N-Glycyl-D-leucine;(R)-2-(2-Aminoacetamido)-4-methylpentanoicacid;N-(Aminoacetyl)leucine, D-;CHEMBL53813;DTXSID001017042;MFCD00066050;AKOS010366803;AKOS015855074;BS-44085;CS-0119991;G0130;T72827;A866968

Chemical Property of Glycyl-d-leucine

Chemical Property:

• Vapor Pressure: 6.97E-08mmHg at 25°C
• Melting Point: 234 °C
• Refractive Index: 35 ° (C=2, H2O)
• Boiling Point: 410.4 °C at 760 mmHg
• PKA: 3.15±0.10(Predicted)
• Flash Point: 202 °C
• PSA: 92.42000
• Density: 1.136 g/cm³
• LogP: 0.65180
• Water Solubility.: almost transparency
• XLogP3: -2.3
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 188.11609238
• Heavy Atom Count: 13
• Complexity: 192

Purity/Quality:

98%,99%, ^*data from raw suppliers

Glycyl-D-leucine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CC(C(=O)O)NC(=O)CN
• Isomeric SMILES: CC(C)C[C@H](C(=O)O)NC(=O)CN

Technology Process of Glycyl-d-leucine

There total 5 articles about Glycyl-d-leucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-leucine (328-38-1,21675-61-6,25248-98-0,70-45-1) → glycyl-D-leucine (688-13-1)

Guidance literature:

Multi-step reaction with 3 steps

1: HCl

2: diethyl ether / Behandlung des Reaktionsprodukts mit wss.-methanol. NaOH

3: palladium; acetic acid; methanol / Hydrogenation

With hydrogenchloride; methanol; diethyl ether; palladium; acetic acid;

DOI:10.1021/ja01855a020

Reference yield:

N-benzyloxycarbonylglycyl-D-leucine (57818-73-2) → glycyl-D-leucine (688-13-1)

Guidance literature:

With methanol; palladium; acetic acid; Hydrogenation;

DOI:10.1021/ja01855a020

Reference yield:

D-leucine methyl ester (23032-21-5) → glycyl-D-leucine (688-13-1)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether / Behandlung des Reaktionsprodukts mit wss.-methanol. NaOH

2: palladium; acetic acid; methanol / Hydrogenation

With methanol; diethyl ether; palladium; acetic acid;

DOI:10.1021/ja01855a020

upstream raw materials:

glycylleucine

N-chloroacetyl-D-leucine

N-benzyloxycarbonylglycyl-D-leucine

(R)-leucine

Downstream raw materials:

N-benzyloxycarbonylglycyl-D-leucine

(R)-leucine

glycine

N-benzyloxycarbonylglycyl-D-leucylglycine benzyl ester