Silane, (1,1-dimethylethyl)[[3-methoxy-2-(2-propenyl)phenyl]methoxy]dimethyl-

Base Information

• Chemical Name: Silane, (1,1-dimethylethyl)[[3-methoxy-2-(2-propenyl)phenyl]methoxy]dimethyl-
• CAS No.: 223734-55-2
• Molecular Formula: C17H28O2Si
• Molecular Weight: 292.494
• Mol file: 223734-55-2.mol

Synonyms:

Chemical Property of Silane, (1,1-dimethylethyl)[[3-methoxy-2-(2-propenyl)phenyl]methoxy]dimethyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Silane, (1,1-dimethylethyl)[[3-methoxy-2-(2-propenyl)phenyl]methoxy]dimethyl-

There total 2 articles about Silane, (1,1-dimethylethyl)[[3-methoxy-2-(2-propenyl)phenyl]methoxy]dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 2-allyl-3-methoxy-O-tert-butyldimethylsilylbenzyl alcohol (223734-55-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / imidazole / dimethylformamide / 25 °C

2: n-BuLi / hexane / 48 h

With 1H-imidazole; n-butyllithium; In hexane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)80765-1

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 2-allyl-3-methoxy-O-tert-butyldimethylsilylbenzyl alcohol (223734-55-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / imidazole / CH₂Cl₂

2: n-BuLi / hexane / 24 h / 0 - 20 °C

With 1H-imidazole; n-butyllithium; In hexane; dichloromethane;

DOI:10.1021/jo0347720

Reference yield:

2-allyl-3-methoxy-O-tert-butyldimethylsilylbenzyl alcohol (223734-55-2) → 2-allyl-3-methoxybenzaldehyde (94956-98-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 4695 g / TBAF / tetrahydrofuran / 20 °C

2: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - 20 °C

With oxalyl dichloride; tetrabutyl ammonium fluoride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; 2: Swern oxidation;

DOI:10.1021/jo0347720

upstream raw materials:

tert-butyldimethylsilyl chloride

Downstream raw materials:

(2-allyl-3-methoxyphenyl)methanol

2-allyl-3-methoxybenzaldehyde

treprostinil

(1R,2R,3aS,9aS)-2,3,3a,4,9,9a-hexahydro-1-((S)-3-hydroxyoctyl)-1H-cyclopenta[b]naphthalene-2,5-diol

Refernces

• 1、 -. "METHODS OF SYNTHESIZING A PROSTACYCLIN ANALOG". . . Retrieved 2014/06/24.
• 2、 Negishi, El-Ichi,Coperet, Christophe,Sugihara, Takumichi,Shimoyama, Izumi,Zhang, Yantao,Wu, Guangzhong,Tour, James M.. "Palladium-catalyzed carbonylative cyclization via trapping of acylpalladium derivatives with internal enolates. Its scope and factors affecting the C-to-O ratio". . p. 425 - 436. Retrieved 2007/10/02.