Phenazepam

Base Information

• Chemical Name: Phenazepam
• CAS No.: 51753-57-2
• Deprecated CAS: 66173-95-3
• Molecular Formula: C15H10BrClN2O
• Molecular Weight: 349.614
• European Community (EC) Number: 682-231-2
• UNII: 3DSB43090Z
• DSSTox Substance ID: DTXSID00199685
• Nikkaji Number: J22.283F
• Wikipedia: Phenazepam
• Wikidata: Q421138
• NCI Thesaurus Code: C98139
• ChEMBL ID: CHEMBL1709464
• Mol file: 51753-57-2.mol

Synonyms:7-bromo-5-(2-chlorophenyl) 1,3-dihydro-2H-1,4-benzodiazepin-2-one;7-bromo-5-(2-chlorphenyl)-1,2-dihydro-3H-1,4-benzodiazepin-2-one;fenazepam;phenazepam;phenazepam, 2-(14)C-labeled cpd

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Phenazepam

Chemical Property:

• Appearance/Colour: White or off-white crystalline powder
• Melting Point: 225-230oC
• Refractive Index: 1.691
• Boiling Point: 493 °C at 760 mmHg
• PKA: 11.58±0.70(Predicted)
• Flash Point: 251.9 °C
• Density: 1.61 g/cm³
• Storage Temp.: Controlled Substance, -20°C Freezer
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 347.96650
• Heavy Atom Count: 20
• Complexity: 415

Purity/Quality:

Safty Information:

• Pictogram(s): F,Xn
• Hazard Codes: F,Xn
• Statements: 11-20/21/22-36
• Safety Statements: 16-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(=O)NC2=C(C=C(C=C2)Br)C(=N1)C3=CC=CC=C3Cl
• Description: Phenazepam (CRM) (Item No. ISO60172) is a certified reference material categorized as a benzodiazepine. It has sedative and hypnotic properties and has been detected in illicit tablets. This product is intended for research and forensic applications.
• Uses: 7-Bromo-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-Benzodiazepin-2-one is used in the treatment of neurological disorders such as epilepsy, alcohol withdrawal and insomnia. It can be used as a premedication before surgery as it augments the effects of anesthetics and reduces anxiety

Technology Process of Phenazepam

There total 4 articles about Phenazepam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

phthalic acid hydrazide (16437-59-5) + 5-bromo-2'-chloro-2-(phthalimidoacetamido)benzophenone (87213-48-7) → phenazepam (51753-57-2)

Guidance literature:

With hydrazine hydrate; In methanol; 1.) 60 deg C, 3 h, 2.) R_.T_. 30 min.;

DOI:10.1135/cccc19831477

Reference yield:

2-Bromoacetyl bromide (598-21-0) + (2-amino-5-bromophenyl)(2-chlorophenyl)methanone (60773-49-1) → phenazepam (51753-57-2)

Guidance literature:

2-Bromoacetyl bromide; (2-amino-5-bromophenyl)(2-chlorophenyl)methanone; With sodium hydrogencarbonate;

With ammonia; In methanol;

Reference yield:

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone (60773-49-1) → phenazepam (51753-57-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / CHCl₃ / 5 h / Heating

2: 90 percent / 18 percent aq. N₂H₄ / methanol / 1.) 60 deg C, 3 h, 2.) R_.T_. 30 min.

With hydrazine hydrate; In methanol; chloroform;

DOI:10.1135/cccc19831477

upstream raw materials:

phthalic acid hydrazide

5-bromo-2'-chloro-2-(phthalimidoacetamido)benzophenone

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone

2-Bromoacetyl bromide

Downstream raw materials:

8-bromo-5-(2-chlorophenyl)-1-methyl-4H-s-triazolo<4,3-a>-1,4-benzodiazepine

8-bromo-5-(2-chlorophenyl)-1-(methylthiomethyl)-4H-s-triazolo<4,3-a>-1,4-benzodiazepine

C₂₁H₁₃BrClN₃O

C₂₂H₁₃Br₂ClN₂O

Refernces

• 1、 -. "ANXIOLYTIC AGENTS WITH REDUCED SEDATIVE AND ATAXIC EFFECTS". Page/Page column 49. . Retrieved 2010/02/07.