1-(4-BIPHENYLYL)-4,4,4-TRIFLUORO-1,3-BUTANEDIONE

Base Information

• Chemical Name: 1-(4-BIPHENYLYL)-4,4,4-TRIFLUORO-1,3-BUTANEDIONE
• CAS No.: 581-83-9
• Molecular Formula: C16H11F3O2
• Molecular Weight: 292.2525
• Mol file: 581-83-9.mol

Synonyms:1-(4-Biphenylyl)-4,4,4-trifluoro-1,3-butanedione;1-(4-phenylphenyl)-4,4,4-trifluorobutane-1,3-dione;1-biphenyl-4-yl-4,4,4-trifluoro-butane-1,3-dione;4,4,4-Trifluor-1-{biphenylyl-(4)}-butandion-(1,3);1-Biphenyl-4-yl-4,4,4-trifluor-butan-1,3-dion;4,4,4-trifluoro-1-(biphenylyl-4)-1,3-butanedione;

Chemical Property of 1-(4-BIPHENYLYL)-4,4,4-TRIFLUORO-1,3-BUTANEDIONE

Chemical Property:

• Vapor Pressure: 9.3E-06mmHg at 25°C
• Boiling Point: 372.9°Cat760mmHg
• Flash Point: 134.3°C
• PSA: 34.14000
• Density: 1.255g/cm³
• LogP: 4.05780

Purity/Quality:

99% ^*data from raw suppliers

1-(4-BIPHENYLYL)-4,4,4-TRIFLUORO-1,3-BUTANEDIONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-BIPHENYLYL)-4,4,4-TRIFLUORO-1,3-BUTANEDIONE

There total 3 articles about 1-(4-BIPHENYLYL)-4,4,4-TRIFLUORO-1,3-BUTANEDIONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

biphenyl-4-acetaldehyde (92-91-1) + ethyl trifluoroacetate, (383-63-1) → 1-([1,1'-biphenyl]-4-yl)-4,4,4-trifluorobutane-1,3-dione (581-83-9)

Guidance literature:

biphenyl-4-acetaldehyde; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

ethyl trifluoroacetate,; In tetrahydrofuran; at 0 - 25 ℃; for 12h;

DOI:10.1021/acs.oprd.9b00212

Reference yield:

biphenyl-4-acetaldehyde (92-91-1) + 2,2,2-trifluoroethyl trifluoroacetate (407-38-5) → 1-([1,1'-biphenyl]-4-yl)-4,4,4-trifluorobutane-1,3-dione (581-83-9)

Guidance literature:

biphenyl-4-acetaldehyde; With n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; hexane; at -78 ℃; for 0.583333h; Inert atmosphere;

2,2,2-trifluoroethyl trifluoroacetate; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h; Inert atmosphere;

DOI:10.1002/adsc.201600980

Reference yield:

→ 1-([1,1'-biphenyl]-4-yl)-4,4,4-trifluorobutane-1,3-dione (581-83-9)

Guidance literature:

aus /BRN= 101615/, CF3-COO-C2H5;

DOI:10.1016/0022-1902(67)80328-2

upstream raw materials:

biphenyl-4-acetaldehyde

ethyl trifluoroacetate,

2,2,2-trifluoroethyl trifluoroacetate

Downstream raw materials:

4-(5-biphenyl-4-yl-3-trifluoromethyl-pyrazol-1-yl)-phenylamine

N-[4-(5-biphenyl-4-yl-3-trifluoromethyl-pyrazol-1-yl)-phenyl]-aminosulfonamide

5-Biphenyl-4-yl-1-(4-nitro-phenyl)-3-trifluoromethyl-1H-pyrazole

4-(5-(biphenyl-4-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide

Refernces

• 1、 Kale, Balaji S.,Lee, Hsin-Fu,Liu, Rai-Shung. "A Sequential Route to Cyclopentenes from 1,6-Enynes and Diazo Ketones through Gold and Rhodium Catalysis". supporting information. p. 402 - 409. Retrieved 2017/02/10.
• 2、 Büttner, Stefan,Riahi, Abdolmajid,Hussain, Ibrar,Yawer, Mirza A.,Lubbe, Mathias,Villinger, Alexander,Reinke, Helmut,Fischer, Christine,Langer, Peter. "First synthesis of functionalized 5-aryl-3-(trifluoromethyl)phenols by regioselective [3+3] cyclocondensations of 1,3-bis(silyloxy)-1,3-butadienes with 3-aryl-3-silyloxy-1-trifluoromethyl-2-en-1-ones". experimental part. p. 2124 - 2135. Retrieved 2009/07/18.