8-Oxaspiro[4.5]decane-7,9-dione

Base Information

• Chemical Name: 8-Oxaspiro[4.5]decane-7,9-dione
• CAS No.: 5662-95-3
• Molecular Formula: C9H12 O3
• Molecular Weight: 168.192
• Hs Code.: 2917209090
• European Community (EC) Number: 227-116-6
• NSC Number: 78448
• DSSTox Substance ID: DTXSID20205196
• Nikkaji Number: J208.216K
• Wikidata: Q72507639
• Mol file: 5662-95-3.mol

Synonyms:3,3-tetramethyleneglutaric anhydride

Chemical Property of 8-Oxaspiro[4.5]decane-7,9-dione

Chemical Property:

• Appearance/Colour: white glistening crystals
• Vapor Pressure: 0.000277mmHg at 25°C
• Melting Point: 64-66 ºC
• Refractive Index: 1.5330 (estimate)
• Boiling Point: 186 ºC (15 mmHg),322.6 °C at 760 mmHg
• Flash Point: 154.5 °C
• PSA: 43.37000
• Density: 1.19 g/cm³
• LogP: 1.41040
• Storage Temp.: Inert atmosphere,Room Temperature
• Water Solubility.: decomposes
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 168.078644241
• Heavy Atom Count: 12
• Complexity: 208

Purity/Quality:

98%,99%, ^*data from raw suppliers

1,1-Cyclopentanediacetic Anhydride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CCC2(C1)CC(=O)OC(=O)C2
• Uses: 1,1-Cyclopentanediacetic Anhydride is used to prepare betulin carboxyalkanoate derivatives as anti-HIV agents.

Technology Process of 8-Oxaspiro[4.5]decane-7,9-dione

There total 5 articles about 8-Oxaspiro[4.5]decane-7,9-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

→ 3,3-tetramethylene glutaric anhydride (5662-95-3)

Guidance literature:

Reference yield:

1,1-cyclopentanediacetic acid (16713-66-9) → 3,3-tetramethylene glutaric anhydride (5662-95-3)

Guidance literature:

With acetic anhydride; acetyl chloride;

Reference yield:

[1-(carbamoyl-carboxy-methyl)-cyclopentyl]-malonic acid (861342-71-4) → 3,3-tetramethylene glutaric anhydride (5662-95-3)

Guidance literature:

Multi-step reaction with 3 steps

1: NaOH-solution

2: 169 °C

3: acetic acid anhydride; acetyl chloride

With sodium hydroxide; acetic anhydride; acetyl chloride;

upstream raw materials:

1,1-cyclopentanediacetic acid

[1-(carbamoyl-carboxy-methyl)-cyclopentyl]-malonic acid

cyclopentylidenedi-malonic acid

7,9-dioxo-8-azaspiro[4.5]decane-6,10-dicarbonitrile

Downstream raw materials:

8-p-Tolyl-8-aza-spiro[4.5]decane-7,9-dione

8-(4-Chloro-phenyl)-8-aza-spiro[4.5]decane-7,9-dione

4-(7,9-Dioxo-8-aza-spiro[4.5]dec-8-yl)-benzoic acid

2-(7,9-Dioxo-8-aza-spiro[4.5]dec-8-yl)-benzoic acid

Refernces

• 1、 Popovi?-Djordjevi?, Jelena B.,Klaus, Anita S.,?i?ak, ?eljko S.,Mati?, Ivana Z.,Drakuli?, Branko J.. "Antiproliferative and antibacterial activity of some glutarimide derivatives". . p. 915 - 923. Retrieved 2016/10/09.
• 2、 -. "METHOD FOR PRODUCING CARBOXYLIC ANHYDRIDE AND ARYLBORONIC ACID COMPOUND". Page/Page column 14. . Retrieved 2012/01/13.